05-554 | Anti-KDR/Flk-1/VEGFR2 Antibody, clone CH-11

05-554
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MELISA, ICC, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-554
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-KDR/Flk-1/VEGFR2 Antibody, clone CH-11
      References
      Product Information
      FormatPurified
      Presentation20mM sodium phosphate, pH 7.6, 250mM NaCl with 0.1% sodium azide
      Applications
      ApplicationAnti-KDR/Flk-1/VEGFR2 Antibody, clone CH-11 detects level of KDR/Flk-1/VEGFR2 & has been published & validated for use in ELISA, IC & WB.
      Key Applications
      • ELISA
      • Immunocytochemistry
      • Western Blotting
      Biological Information
      ImmunogenRecombinant protein corresponding to residues 1158-1345 of murine KDR/Flk-1
      Cloneclone CH-11
      HostMouse
      SpecificityKDR/Flk-1
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KDR
      • VEGFR-2
      • VEGFR2
      • VEGFR
      • CD309
      • FLK1
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P35968 # Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
      SIZE: 1356 amino acids; 151527 Da
      SUBUNIT: Interacts with SHB upon VEGF activation. Interacts with HIV-1 Tat.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P35968 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 7 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
      Molecular Weight230kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from HUVEC cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at 4°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-KDR/Flk-1, clone CH-11 (mouse monoclonal IgG1) - 2023280 2023280
      Anti-KDR/Flk-1, clone CH-11 (mouse monoclonal IgG1) - 2093487 2093487
      Anti-KDR/Flk-1, clone CH-11 (mouse monoclonal IgG1) - 2243495 2243495
      Anti-KDR/Flk-1, clone CH-11 (mouse monoclonal IgG1) - 2360566 2360566
      Anti-KDR/Flk-1, clone CH-11 - DAM1601823 DAM1601823
      Anti-KDR/Flk-1, clone CH-11 - DAM1644545 DAM1644545
      Anti-KDR/Flk-1, clone CH-11 - DAM1676165 DAM1676165
      Anti-KDR/Flk-1, clone CH-11 - DAM1698717 DAM1698717
      Anti-KDR/Flk-1, clone CH-11 - DAM1724838 DAM1724838
      Anti-KDR/Flk-1, clone CH-11 - DAM1749922 DAM1749922

      References

      Reference overviewPub Med ID
      Role of plasma membrane caveolae/lipid rafts in VEGF-induced redox signaling in human leukemia cells.
      Caliceti, C; Zambonin, L; Rizzo, B; Fiorentini, D; Vieceli Dalla Sega, F; Hrelia, S; Prata, C
      BioMed research international  2014  857504  2014

      Show Abstract
      24738074 24738074

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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies