07-529 | Anti-KIF21A Antibody

07-529
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number07-529
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-KIF21A Antibody
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      Applications
      ApplicationAnti-KIF21A Antibody is an antibody against KIF21A for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenPeptide corresponding to amino acids 948-963 of mouse KIF21A with an N-terminal cysteine added for conjugation purposes.
      HostRabbit
      SpecificityKIF21A
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryKIF21A belongs to a family of plus end-directed kinesin (see MIM 600025) motor proteins. Neurons use kinesin and dynein (see MIM 600112) microtubule-dependent motor proteins to transport essential cellular components along axonal and dendritic microtubules.[supplied by OMIM]
      Gene Symbol
      • KIF21A
      • FLJ20052
      • FEOM
      • CFEOM1
      • DKFZp779C159
      • KIAA1708
      • FEOM1
      • CFEOM
      • KIF2
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q7Z4S6 # Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity).
      SIZE: 1674 amino acids; 187179 Da
      DISEASE: SwissProt: Q7Z4S6 # Defects in KIF21A are a cause of congenital fibrosis of extraocular muscles type 1 (CFEOM1) [MIM:135700]; also known FEOM1. CFEOM1 is characterized by ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves.
      SIMILARITY: SwissProt: Q7Z4S6 ## Belongs to the kinesin-like protein family. & Contains 1 kinesin-motor domain. & Contains 7 WD repeats.
      Molecular Weight180 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot in a rat brain microsomal preparation
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-KIF21A - 26708 26708
      Anti-KIF21A -2548719 2548719
      Anti-KIF21A -2754898 2754898

      References

      Reference overviewPub Med ID
      CFEOM1-Associated Kinesin KIF21A Is a Cortical Microtubule Growth Inhibitor.
      van der Vaart, Babet, et al.
      Dev. Cell, (2013)  2013

      Show Abstract
      24120883 24120883
      KIF1Bbeta2, capable of interacting with CHP, is localized to synaptic vesicles.
      Nakamura, Norihiro, et al.
      J. Biochem., 132: 483-91 (2002)  2002

      Show Abstract
      12204119 12204119
      Novel dendritic kinesin sorting identified by different process targeting of two related kinesins: KIF21A and KIF21B.
      Marszalek, J R, et al.
      J. Cell Biol., 145: 469-79 (1999)  1999

      Show Abstract
      10225949 10225949