06-1404 | Anti-KLF11 Antibody

06-1404
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbSerumPolyclonal Antibody
      Description
      Catalogue Number06-1404
      DescriptionAnti-KLF11 Antibody
      Alternate Names
      • Kruppel-like factor 11
      • TGFB inducible early growth response 2
      • TGFB-inducible early growth response protein 2
      • Transforming growth factor-beta-inducible early growth response protein 2
      Background InformationKrueppel-like factor 11 is a TGF-β-inducible member of the Sp1/KLF family of transcription factors. This protein activates the epsilon- and gamma-globin gene promoters and represses promoters containing SP1-like binding sites. It is demonstrated to be a negative regulator of exocrine tissue growth in vitro and in vivo and to act as a tumor repressor in pancreatic cancer. KLF11 is known to interact with SIN3A.
      References
      Product Information
      FormatSerum
      Control
      • HeLa cell lysate
      PresentationUnpurified rabbit polyclonal in serum with 0.05% sodium azide.
      Applications
      ApplicationAnti-KLF11 Antibody is a Rabbit Polyclonal Antibody for detection of KLF11 also known as Kruppel-like factor 11, TGFB inducible early growth response 2 & has been validated in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human KLF11.
      EpitopeUnknown
      HostRabbit
      SpecificityThis antibody recognizes KLF11.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KLF11
      • FKLF
      • FKLF1
      • MODY7
      • TIEG-2
      • TIEG2
      • Tieg3
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.

      SUBCELLULAR LOCATION: Nucleus.

      TISSUE SPECIFICITY: Ubiquitous. Higher expression in erythroid cells.

      INDUCTION: By TGF-beta.

      INVOLVEMENT IN DISEASE: Defects in KLF11 are the cause of maturity-onset diabetes of the young type 7 (MODY7) [MIM:610508]. MODY [MIM:606391] has an autosomal dominant inheritance, onset at age less than 25 years and a primary defect in insulin secretion. MODY pedigrees are usually multigenerational families with penetrance of 80 to 95%. Patients have a nonobese body habitus and the so-called metabolic syndrome characterized by diabetes, insulin resistance, hypertension, and hypertriglyceridemia is absent.

      SEQUENCE SIMILARITIES: Belongs to the Sp1 C2H2-type zinc-finger protein family.

      Contains 3 C2H2-type zinc fingers.

      CAUTION: Ref.3 sequence was originally thought to originate from mouse.
      Molecular WeightPredicted MW is ~56 kDa.
      Observed MW is ~70 kDa.
      An independent laboratory showed that the observed molecular weight runs at ~70 kDa on western blot.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa cell lysate.

      Western Blot Analysis: 1:1,000 dilution of this antibody detected KLF11 on 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications