06-207 | Anti-Lyn Antibody

06-207
250 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIP, WBRbSerumPolyclonal Antibody
      Description
      Catalogue Number06-207
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Lyn Antibody
      References
      Product Information
      FormatSerum
      Presentationwhole antiserum containing 0.05% sodium azide
      Applications
      ApplicationAnti-Lyn Antibody detects level of Lyn & has been published & validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      Immunogenpeptide (NKQQRPVPESQL-LPGQRFQT) corresponding to residues 39-58 of human Lyn
      HostRabbit
      Specificitytwo known forms of human Lyn
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • LYN
      • FLJ26625
      • JTK8
      Purification MethodAntiserum
      UniProt Number
      UniProt SummarySIZE: 512 amino acids; 58574 Da
      SUBUNIT: Interacts with phosphorylated LIME1 and with CD79A upon BCR activation. Interacts with Epstein-Barr virus LMP2A. Interacts with TGFB1I1.
      TISSUE SPECIFICITY: Expressed in primary neuroblastoma tumors.
      SIMILARITY: SwissProt: P07948 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
      Molecular Weight53 and 56kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from human A431 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size250 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Lyn (rabbit antiserum) - 2383125 2383125
      Anti-Lyn (rabbit antiserum) 2479780
      Anti-Lyn (rabbit antiserum) 2906304
      Anti-Lyn (rabbit antiserum) - 2225235 2225235
      Anti-Lyn (rabbit antiserum) - DAM1661048 DAM1661048
      Anti-Lyn - 15848 15848
      Anti-Lyn - 19449 19449
      Anti-Lyn - 26020 26020

      References

      Reference overviewApplicationPub Med ID
      Lyn is a target gene for prostate cancer: sequence-based inhibition induces regression of human tumor xenografts.
      Mirela Goldenberg-Furmanov, Ilan Stein, Eli Pikarsky, Hila Rubin, Shafika Kasem, Marc Wygoda, Irina Weinstein, Hadas Reuveni, Shmuel A Ben-Sasson
      Cancer research  64  1058-66  2004

      Show Abstract
      14871838 14871838
      Volume expansion stimulates p72(syk) and p56(lyn) in skate erythrocytes.
      Musch, M W, et al.
      J. Biol. Chem., 274: 7923-8 (1999)  1999

      Show Abstract
      Kinase Assay10075687 10075687
      Interleukin 5 signals through Shc and Grb2 in human eosinophils
      Bates, M. E., et al
      Am J Respir Cell Mol Biol, 18:75-83 (1998)  1998

      Immunoblotting (Western)9448048 9448048
      Genetic evidence for a tyrosine kinase cascade preceding the mitogen-activated protein kinase cascade in vertebrate G protein signaling
      Wan, Y., et al
      J Biol Chem, 272:17209-15 (1997)  1997

      Kinase Assay9202044 9202044
      The unique domain as the site on Lyn kinase for its constitutive association with the high affinity receptor for IgE.
      Vonakis, B M, et al.
      J. Biol. Chem., 272: 24072-80 (1997)  1997

      Show Abstract
      Immunoblotting (Western)9295361 9295361
      Signaling through intercellular adhesion molecule 1 (ICAM-1) in a B cell lymphoma line. The activation of Lyn tyrosine kinase and the mitogen-activated protein kinase pathway
      Holland, J. and Owens, T.
      J Biol Chem, 272:9108-12 (1997)  1997

      Immunoprecipitation9083038 9083038
      The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck.
      Yamanashi, Y, et al.
      Mol. Cell. Biol., 7: 237-43 (1987)  1987

      Show Abstract
      3561390 3561390

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies