05-346 | Anti-MAP2 Antibody, clone 5F9

05-346
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R, RbWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-346
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-MAP2 Antibody, clone 5F9
      References
      Product Information
      FormatPurified
      Presentation200 µg of protein G purified mouse IgG1 in 200 µL of storage buffer (0.02 M phosphate buffer, pH 7.6, 0.25 M NaCl, and 0.1% sodium azide. Frozen at -20°C.
      Applications
      ApplicationDetect MAP2 using this Anti-MAP2 Antibody, clone 5F9 validated for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Biological Information
      ImmunogenPurified rat brain microtubules MAP2
      Cloneclone 5F9
      HostMouse
      SpecificityMAP2
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      • Rat
      • Rabbit
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe MAP2 gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described.
      Gene Symbol
      • MAP2
      • MAP2A
      • MAP2B
      Purification MethodProtein G Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P11137 # The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
      SIZE: 1,827 amino acids (Isofoim 1; MAP2b); 471 amino acids (Isofoim 2; MAP2c); 1,823 amino acids (Isofoim 3; MAP2a); 559 amino acids (Isofoim 4; MAP2d);
      SUBCELLULAR LOCATION: Cytoplasm. Cytoskeleton.
      PTM: Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly. Isoform 2/MAP2c is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67.
      Molecular Weight300kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated on rat brain microsomal preparation (Catalog #12-144).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-MAP2, clone 5F9 (mouse monoclonal IgG1) - 2140543 2140543
      Anti-MAP2, clone 5F9 (mouse monoclonal IgG1) - 2397122 2397122
      Anti-MAP2, clone 5F9 (mouse monoclonal IgG1) - 2465236 2465236
      Anti-MAP2, clone 5F9 (mouse monoclonal IgG1) 2857197
      Anti-MAP2, clone 5F9 (mouse monoclonal IgG1) 2913388
      Anti-MAP2, clone 5F9 (mouse monoclonal IgG1) - 2089510 2089510
      Anti-MAP2, clone 5F9 (mouse monoclonal IgG1) - 2278507 2278507
      Anti-MAP2, clone 5F9 (mouse monoclonal IgG1) - DAM1498219 DAM1498219
      Anti-MAP2, clone 5F9 (mouse monoclonal IgG1) - R0802C0016 R0802C0016
      Anti-MAP2, clone 5F9 - 0701049386 0701049386

      References

      Reference overviewApplicationPub Med ID
      p53 regulates neural stem cell proliferation and differentiation via BMP-Smad1 signaling and Id1.
      Liu, H; Jia, D; Li, A; Chau, J; He, D; Ruan, X; Liu, F; Li, J; He, L; Li, B
      Stem cells and development  22  913-27  2013

      Show Abstract
      Immunocytochemistry23199293 23199293
      Activity-dependent regulation of surface glucose transporter-3.
      Ferreira, JM; Burnett, AL; Rameau, GA
      The Journal of neuroscience : the official journal of the Society for Neuroscience  31  1991-9  2011

      Show Abstract Full Text Article
      21307237 21307237
      Loss of activity-induced phosphorylation of MeCP2 enhances synaptogenesis, LTP and spatial memory.
      Li, H; Zhong, X; Chau, KF; Williams, EC; Chang, Q
      Nature neuroscience  14  1001-8  2011

      Show Abstract
      21765426 21765426
      Fusion of microglia with pyramidal neurons after retroviral infection.
      Ackman, JB; Siddiqi, F; Walikonis, RS; LoTurco, JJ
      The Journal of neuroscience : the official journal of the Society for Neuroscience  26  11413-22  2006

      Show Abstract
      17079670 17079670
      Bidirectional regulation of neuronal nitric-oxide synthase phosphorylation at serine 847 by the N-methyl-D-aspartate receptor
      Rameau, G. A., et al
      J Biol Chem, 279:14307-14 (2004)  2004

      Immunohistochemistry (Tissue)14722119 14722119
      Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons
      Eiraku, M., et al
      J Biol Chem, 277:25400-7 (2002)  2002

      Immunohistochemistry11950833 11950833
      Cyclin-dependent kinases as a therapeutic target for stroke.
      Osuga, H; Osuga, S; Wang, F; Fetni, R; Hogan, MJ; Slack, RS; Hakim, AM; Ikeda, JE; Park, DS
      Proceedings of the National Academy of Sciences of the United States of America  97  10254-9  2000

      Show Abstract Full Text Article
      10944192 10944192
      Partial sequence of MAP2 in the region of a shared epitope with Alzheimer neurofibrillary tangles.
      Kosik, K S, et al.
      J. Neurochem., 51: 587-98 (1988)  1988

      Show Abstract
      2455776 2455776
      Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles.
      Kosik, K S, et al.
      Proc. Natl. Acad. Sci. U.S.A., 81: 7941-5 (1984)  1984

      Show Abstract
      6083566 6083566
      Microtubule assembly in the absence of added nucleotides.
      Shelanski, M L, et al.
      Proc. Natl. Acad. Sci. U.S.A., 70: 765-8 (1973)  1973

      Show Abstract
      4514990 4514990

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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies