05-652 | Anti-MUC1/episialin Antibody, clone 214D4

200 µg  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, IHCMPurifiedMonoclonal Antibody
      Catalogue Number05-652
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-MUC1/episialin Antibody, clone 214D4
      Alternate Names
      • Breast carcinoma-associated antigen DF3
      • Carcinoma-associated mucin
      • Episialin
      • H23AG
      • PEMT
      • Peanut-reactive urinary mucin
      • PUM
      • Polymorphic epithelial mucin
      • PEM
      • Tumor-associated epithelial membrane antigen
      • EMA
      • Tumor-associated mucin
      • CD227
      Product Information
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      ApplicationAnti-MUC1/episialin Antibody, clone 214D4 detects level of MUC1/episialin & has been published & validated for use in FC, IH.
      Key Applications
      • Flow Cytometry
      • Immunohistochemistry
      Biological Information
      ImmunogenFusion protein, human b-gal-episialin/MUC1 repeat domain
      Cloneclone 214D4
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined.
      Gene Symbol
      • MUC1
      • MUC1/ZD
      • MUC-1/X
      • PEMT
      • MUC-1
      • Episialin
      • episialin
      • MUC-1/SEC
      • PUM
      • EMA
      • PEM
      • H23AG
      • MAM6
      • CD227
      Purification MethodProtein G Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P15941 # Isoform 7 behaves as a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling. Can bind to GRB2 adapter protein.
      SIZE: 1255 amino acids; 122072 Da
      SUBUNIT: The cleaved form (only the isoform 1) of MUC1 forms a tight heterodimer with the released C-terminal peptide (which is first secreted to be extracellular).
      SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 5: Secreted. & Isoform 9: Secreted.
      TISSUE SPECIFICITY: Expressed on ductal epithelial cells and on activated T-cells. Aberrantly glycosylated forms expressed in human epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform 7 expressed only in tumoral cells.
      PTM: Highly glycosylated (N- and O-linked carbohydrates and sialic acid). In the 20 amino acid tandem repeat positions 5 (Ser), 6 (Thr), 14 (Thr), 15 (Ser) and 19 (Thr) are O-glycosylated (GalNAc). The average density of O-glycosylated sites within repeat peptides varies with cell differentiation from about 50% in lactation-associated MUC1 to over 90% in a variety of breast cancer cells. & Isoform 1 and isoform 7 undergoes transphosphorylation on serine and tyrosine residues.
      SIMILARITY: SwissProt: P15941 ## Contains 1 SEA domain.
      Molecular Weightnone given
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunohistochemistry
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-MUC1/episialin, clone 214D4 (mouse monoclonal IgG1) - 2379350 2379350
      Anti-MUC1/episialin, clone 214D4 (mouse monoclonal IgG1) - 2433385 2433385
      Anti-MUC1/episialin, clone 214D4 (mouse monoclonal IgG1) 2905307
      Anti-MUC1/episialin, clone 214D4 (mouse monoclonal IgG1) 2806554
      Anti-MUC1/episialin, clone 214D4 (mouse monoclonal IgG1) 3137691
      Anti-MUC1/episialin, clone 214D4 (mouse monoclonal IgG1) 2983276
      Anti-MUC1/episialin, clone 214D4 (mouse monoclonal IgG1) - 2279214 2279214
      Anti-MUC1/episialin, clone 214D4 (mouse monoclonal IgG1) - JBC1946375 JBC1946375
      Anti-MUC1/episialin, clone 214D4 - 2399452 2399452
      Anti-MUC1/episialin, clone 214D4 - 1966937 1966937


      Reference overviewPub Med ID
      Raf kinase inhibitor protein (RKIP) blocks signal transducer and activator of transcription 3 (STAT3) activation in breast and prostate cancer.
      Yousuf, S; Duan, M; Moen, EL; Cross-Knorr, S; Brilliant, K; Bonavida, B; LaValle, T; Yeung, KC; Al-Mulla, F; Chin, E; Chatterjee, D
      PloS one  9  e92478  2014

      Show Abstract
      24658061 24658061
      Monoclonal antibodies against the nonmucin domain of MUC1/episialin.
      Hilkens, J and Boer, M
      Tumour Biol., 19 Suppl 1: 67-70 (1998)  1998

      Show Abstract
      9422090 9422090
      A mechanism for inhibition of E-cadherin-mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1.
      Wesseling, J, et al.
      Mol. Biol. Cell, 7: 565-77 (1996)  1996

      Show Abstract
      8730100 8730100

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      Alternative Packsize

      Catalogue Number Description  
      05-652-KC Anti-MUC1/episialin Antibody, clone 214D4 (1mg) KC Show Pricing & Availability
      05-652-CKC Anti-MUC1/episialin Antibody, clone 214D4 (100ug) KC Show Pricing & Availability

      Product Families


      Life Science Research > Antibodies and Assays > Primary Antibodies