05-724MG | Anti-Myc Tag Antibody, clone 4A6

05-724MG
1 mg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIF, IP, WB, ICCMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-724MG
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Myc Tag Antibody, clone 4A6
      OverviewRecognizes and is specific for recombinant proteins containing the Myc epitope tag (EQKLISEEDL) in a variety of sequence contexts. Also recognizes human Myc.
      References
      Product Information
      FormatPurified
      PresentationPBS
      Applications
      ApplicationDetect Myc Tag using this Anti-Myc Tag Antibody, clone 4A6 validated for use in ChIP, IF, IP, WB & IC.
      Key Applications
      • Immunofluorescence
      • Immunoprecipitation
      • Western Blotting
      • Immunocytochemistry
      Biological Information
      Immunogenpeptide corresponding to amino acids 410-420 (MEQKLISEEDL) of human Myc
      Cloneclone 4A6
      HostMouse
      SpecificityRecognizes and is specific for recombinant proteins containing the Myc epitope tag (EQKLISEEDL) in a variety of sequence contexts; also recognizes human Myc.
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
      Gene Symbol
      • MYC
      • C-MYC
      • c-Myc
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01106 # Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.
      SIZE: 439 amino acids; 48804 Da
      SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with JARID1A and JARID1B.
      SUBCELLULAR LOCATION: Nucleus.
      PTM: Phosphorylated by PRKDC.
      DISEASE: SwissProt: P01106 # Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. & A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.
      SIMILARITY: SwissProt: P01106 ## Contains 1 basic helix-loop-helix (bHLH) domain.
      Molecular Weightdependent upon the molecular weight of the tagged protein
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on Myc-tagged recombinant protein in sequence contexts
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Myc Tag, clone 4A6 2470908
      Anti-Myc Tag, clone 4A6 (mouse monoclonal IgG1) - 2385950 2385950
      Anti-Myc Tag, clone 4A6 (mouse monoclonal IgG1) - 2391064 2391064
      Anti-Myc Tag, clone 4A6 (mouse monoclonal IgG1) 2898899
      Anti-Myc Tag, clone 4A6 (mouse monoclonal IgG1) 2927684
      Anti-Myc Tag, clone 4A6 (mouse monoclonal IgG1) - 2234161 2234161
      Anti-Myc Tag, clone 4A6 (mouse monoclonal IgG1) - 2282152 2282152
      Anti-Myc Tag, clone 4A6 (mouse monoclonal IgG1) -2494001 2494001
      Anti-Myc Tag, clone 4A6 - 2040397 2040397
      Anti-Myc Tag, clone 4A6 - 2069365 2069365

      References

      Reference overviewPub Med ID
      Yeast H2A.Z, FACT complex and RSC regulate transcription of tRNA gene through differential dynamics of flanking nucleosomes.
      Mahapatra, S; Dewari, PS; Bhardwaj, A; Bhargava, P
      Nucleic acids research  39  4023-34  2011

      Show Abstract
      21266479 21266479
      Overview of tag protein fusions: from molecular and biochemical fundamentals to commercial systems
      Terpe, K
      Appl Microbiol Biotechnol, 60:523-33 (2003)  2003

      12536251 12536251

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies