05-945 | Anti-NKG2D Antibody, clone 3.1.1.1

05-945
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-945
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-NKG2D Antibody, clone 3.1.1.1
      References
      Product Information
      FormatPurified
      Applications
      ApplicationDetect NKG2D using this Anti-NKG2D Antibody, clone 3.1.1.1 validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogen6His-tagged fusion protein corresponding to residues 85-216 of human NKG2D
      Cloneclone 3.1.1.1
      HostMouse
      SpecificityNKG2D
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryNatural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene encodes a member of the NKG2 family, and the encoded transmembrane protein is characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells.
      Gene Symbol
      • KLRK1
      • KLR
      • NKG2D
      • CD314
      • D12S2489E
      • NKG2-D
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P26718 # Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes.
      SIZE: 216 amino acids; 25274 Da
      SUBUNIT: Homodimer. Interacts with DAP10. The interaction with DAP10 is required for NKG2D cell surface expression.
      SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
      TISSUE SPECIFICITY: Natural killer cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Also detected in gamma-delta cells and CD8+ alpha-beta T-cells.
      SIMILARITY: SwissProt: P26718 ## Contains 1 C-type lectin domain.
      MISCELLANEOUS: Structurally distinct families of ligands for mouse and human NKG2D receptors have been characterized. They might be orthologs.
      Molecular Weight25-42 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot in RIPA lysates from human Natural Killer cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-NKG2D, clone 3.1.1.1 - 30540 30540

      References

      Reference overviewPub Med ID
      Structure of the Ly49 family of natural killer (NK) cell receptors and their interaction with MHC class I molecules.
      Dimasi, Nazzareno, et al.
      Immunol. Res., 30: 95-104 (2004)  2004

      Show Abstract
      15258313 15258313
      UL16 binding proteins.
      Cao, Wei and He, Wei
      Immunobiology, 209: 283-90 (2004)  2004

      Show Abstract
      15518340 15518340
      NKG2D.
      Lanier, L L
      J. Biol. Regul. Homeost. Agents, 17: 338-40 (2003)  2003

      15065764 15065764
      Roles of the NKG2D immunoreceptor and its ligands.
      Raulet, David H
      Nat. Rev. Immunol., 3: 781-90 (2003)  2003

      Show Abstract
      14523385 14523385