05-936 | Anti-ORC2 Antibody, clone 3G6

05-936
50 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIP, WBRPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-936
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-ORC2 Antibody, clone 3G6
      Overviewdna replication origin recognition complex
      References
      Product Information
      FormatPurified
      Applications
      ApplicationDetect ORC2 with Anti-ORC2 Antibody, clone 3G6 (Rat Monoclonal Antibody), that has been shown to work in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenFull-length human origin recognition complex 2 (ORC2). Clone 3G6.
      Cloneclone 3G6
      HostRat
      SpecificityORC2
      IsotypeIgG2a
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3L, -4L, and -5L. It also interacts with CDC45L and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication.
      Gene Symbol
      • ORC2L
      • ORC2
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q13416 # Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.
      SIZE: 577 amino acids; 65972 Da
      SUBUNIT: ORC is composed of six subunits. Interacts with DBF4 (By similarity). Interacts with MCM10.
      SUBCELLULAR LOCATION: Nucleus.
      SIMILARITY: SwissProt: Q13416 ## Belongs to the ORC2 family.
      Molecular Weight65-70kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-ORC2, clone 3G6 (rat monoclonal IgG2a) - 2433224 2433224
      Anti-ORC2, clone 3G6 (rat monoclonal IgG2a) 2944640
      Anti-ORC2, clone 3G6 (rat monoclonal IgG2a) - 1951095 1951095
      Anti-ORC2, clone 3G6 - 1962005 1962005
      Anti-ORC2, clone 3G6 - 30517 30517

      References

      Reference overviewApplicationPub Med ID
      Genome-wide mapping of human DNA-replication origins: levels of transcription at ORC1 sites regulate origin selection and replication timing.
      Dellino, GI; Cittaro, D; Piccioni, R; Luzi, L; Banfi, S; Segalla, S; Cesaroni, M; Mendoza-Maldonado, R; Giacca, M; Pelicci, PG
      Genome research  23  1-11  2013

      Show Abstract
      Western Blotting23187890 23187890
      RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.
      Huen, Michael S Y, et al.
      Cell, 131: 901-14 (2007)  2007

      Show Abstract
      18001825 18001825

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies