05-916 | Anti-P-Cadherin Antibody, clone 6A9

05-916
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIP, WB, ICCMAscitesMonoclonal Antibody
      Description
      Catalogue Number05-916
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-P-Cadherin Antibody, clone 6A9
      References
      Product Information
      FormatAscites
      Applications
      ApplicationThis Anti-P-Cadherin Antibody, clone 6A9 is validated for use in IP, WB, IC for the detection of P-Cadherin.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      • Immunocytochemistry
      Biological Information
      ImmunogenP-Cadherin extracellular domain purified from A431 cell membranes.
      Cloneclone 6A9
      HostMouse
      SpecificityRecognizes P-Cadherin
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.
      Gene Symbol
      • CDH3
      • P-cadherin
      • Placental-cadherin
      • HJMD
      • CDHP
      • PCAD
      Purification MethodAscites
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P22223 # Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
      SIZE: 829 amino acids; 91418 Da
      SUBUNIT: Interacts with CDCP1.
      SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Expressed in some normal epithelial tissues and in some carcinoma cell lines.
      DISEASE: SwissProt: P22223 # Defects in CDH3 are the cause of hypotrichosis with juvenile macular dystrophy (HJMD) [MIM:601553]. HJMD is a rare autosomal recessive disorder characterized by early hair loss heralding severe degenerative changes of the retinal macula and culminating in blindness during the second to third decade of life. & Defects in CDH3 are the cause of EEM syndrome [MIM:225280]; also known as ectodermal dysplasia, ectrodactyly, and macular dystrophy or Albrectsen-Svendsen syndrome or Ohdo- Hirayama-Terawaki syndrome.
      SIMILARITY: SwissProt: P22223 ## Contains 5 cadherin domains.
      Molecular WeightMr 120kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot on A431 cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti- P-Cadherin, clone 6A9 (mouse ascites) 2964102
      Anti- P-Cadherin, clone 6A9 (mouse ascites) 2867061
      Anti- P-Cadherin, clone 6A9 -2570180 2570180
      Anti- P-Cadherin, clone 6A9 -2684224 2684224
      Anti- P-Cadherin, clone 6A9 -2686211 2686211
      Anti- P-Cadherin, clone 6A9 -2707243 2707243
      Anti- P-Cadherin, clone 6A9 -2814672 2814672
      Anti-P-Cadherin, clone 6A9 - 30414 30414

      References

      Reference overviewApplicationPub Med ID
      p120ctn and P-cadherin but not E-cadherin regulate cell motility and invasion of DU145 prostate cancer cells.
      Kümper, S; Ridley, AJ
      PloS one  5  e11801  2010

      Show Abstract Full Text Article
      Western Blotting20668551 20668551
      Identification of human embryonic stem cell surface markers by combined membrane-polysome translation state array analysis and immunotranscriptional profiling.
      Kolle G, Ho M, Zhou Q, Chy HS, Krishnan K, Cloonan N, Bertoncello I, Laslett AL, Grimmond SM
      Stem Cells  27  2446-56.  2009

      Show Abstract
      19650036 19650036
      The cadherin-catenin complex as a focal point of cell adhesion and signalling: new insights from three-dimensional structures.
      Gooding, Jane M, et al.
      Bioessays, 26: 497-511 (2004)  2004

      Show Abstract
      15112230 15112230
      Structure-based models of cadherin-mediated cell adhesion: the evolution continues.
      Koch, A W, et al.
      Cell. Mol. Life Sci., 61: 1884-95 (2004)  2004

      Show Abstract
      15289931 15289931
      Differential displacement of classical cadherins by VE-cadherin
      Jaggi, M., et al
      Cell Commun Adhes, 9:103-15 (2002)  2002

      Immunoprecipitation12487411 12487411
      Lack of correlation between serum levels of E- and P-cadherin fragments and the presence of breast cancer.
      Knudsen, K A, et al.
      Hum. Pathol., 31: 961-5 (2000)  2000

      Show Abstract
      Immunoblotting (Western)10987257 10987257
      Mechanism of extracellular domain-deleted dominant negative cadherins.
      Nieman, M T, et al.
      J. Cell. Sci., 112 ( Pt 10): 1621-32 (1999)  1999

      Show Abstract
      Immunoblotting (Western)10212155 10212155
      Inhibition of cadherin function differentially affects markers of terminal differentiation in cultured human keratinocytes
      Hines, M. D., et al
      J Cell Sci, 112 ( Pt 24):4569-79 (1999)  1999

      Neutralization Assay10574706 10574706
      Cadherin function is required for human keratinocytes to assemble desmosomes and stratify in response to calcium
      Lewis, J. E., et al
      J Invest Dermatol, 102:870-7 (1994)  1994

      Immunoblotting (Western), Immunoprecipitation8006450 8006450

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies