06-222 Anti-PP2A Antibody, C subunit

200 µg  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R, RbIP, WBRbSerumPolyclonal Antibody
      Catalogue Number06-222
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-PP2A Antibody, C subunit
      Product Information
      • Positive Control Included: Non-Stim A431 Cell Lysate (12-301). Other controls: HeLa whole cel lysate, mouse NIH3T3 cells
      PresentationImmunoaffinity Purified immunoglobulin in 150mM Tris, pH 7.4, 0.02% sodium azide, 50% glycerol and 5mg/ml BSA
      ApplicationAnti-PP2A Antibody, C subunit is an antibody against PP2A for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      Immunogenpeptide corresponding to the C-terminal amino acid residues 296-309 of human protein phosphatase 2A
      SpecificityRecognizes PP2A-subunit alpha and PP2A-subunit beta; does not react with PP1 or other protein phosphatases.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      • Rabbit
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.
      Gene Symbol
      • PPP2CA
      • PP2CA
      • PP2A-alpha
      • RP-C
      • PP2Ac
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P67775 # PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Can dephosphorylate SV40 large T antigen and p53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen.
      COFACTOR: Binds 1 iron ion per subunit; Binds 1 manganese ion per subunit
      SIZE: 309 amino acids; 35594 Da
      SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with NXN; the interaction is direct.
      SIMILARITY: SwissProt: P67775 ## Belongs to the PPP phosphatase family. PP-1 subfamily.
      Molecular Weight36 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on a rabbit brain cytosol or in a human A431 RIPA cell lysate
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-PP2A (Protein Phosphatase-2A) (rabbit polyclonal IgG) - DAM1416548DAM1416548
      Anti-PP2A (Protein Phosphatase-2A) - 19723151972315
      Anti-PP2A (Protein Phosphatase-2A) - DAM1764407DAM1764407
      Anti-PP2A (Protein Phosphatase-2A) - DAM1834938DAM1834938
      Anti-PP2A (Protein Phosphatase-2A) - JBC1856026JBC1856026
      Anti-PP2A (Protein Phosphatase-2A) - JBC1909548JBC1909548
      Anti-PP2A (Protein Phosphatase-2A) -25240672524067
      Anti-PP2A (Protein Phosphatase-2A) -25857022585702
      Anti-PP2A (Protein Phosphatase-2A) -26346322634632
      Anti-PP2A (Protein Phosphatase-2A) -27145472714547


      Reference overviewApplicationSpeciesPub Med ID
      Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson's disease.
      Lee, KW; Im, JY; Woo, JM; Grosso, H; Kim, YS; Cristovao, AC; Sonsalla, PK; Schuster, DS; Jalbut, MM; Fernandez, JR; Voronkov, M; Junn, E; Braithwaite, SP; Stock, JB; Mouradian, MM
      Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics  10  143-53  2013

      Show Abstract
      23296837 23296837
      Afferent arteriolar dilation to 11, 12-EET analogs involves PP2A activity and Ca2+-activated K+ Channels.
      John D Imig,Christiana Dimitropoulou,D Sudarshan Reddy,Richard E White,John R Falck
      Microcirculation (New York, N.Y. : 1994)  15  2008

      Show Abstract Full Text Article
      18260004 18260004
      Functional interaction of Aurora-A and PP2A during mitosis.
      Horn, V; Thélu, J; Garcia, A; Albigès-Rizo, C; Block, MR; Viallet, J
      Molecular biology of the cell  18  1233-41  2007

      Show Abstract
      Human17229885 17229885
      Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells.
      Peng, X; Peng, XM; Tehranian, R; Dietrich, P; Stefanis, L; Perez, RG
      Journal of cell science  118  3523-30  2005

      Show Abstract
      Immunoprecipitation16030137 16030137
      The serine phosphatases PP1 and PP2A associate with and activate the actin-binding protein cofilin in human T lymphocytes
      Ambach, A., et al
      Eur J Immunol, 30:3422-31 (2000)  2000

      Phosphatase Assay11093160 11093160
      Association of cystic fibrosis transmembrane conductance regulator and protein phosphatase 2C.
      T Zhu, D Dahan, A Evagelidis, S Zheng, J Luo, J W Hanrahan
      The Journal of biological chemistry  274  29102-7  1999

      Show Abstract
      Immunoblotting (Western)Hamster10506164 10506164
      Postnatal changes in contractile time parameters, calcium regulatory proteins, and phosphatases
      Gombosova, I, et al.
      Am J Physiol, 274:H2123-H2132 (1998)  1998

      Immunoblotting (Western)Rat9841539 9841539
      cAMP counter-regulates insulin-mediated protein phosphatase-2A inactivation in rat skeletal muscle cells
      Begum, N. and Ragolia, L.
      J Biol Chem, 271:31166-71 (1996)  1996

      Immunoprecipitation8940115 8940115
      CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression
      Bito, H., et al
      Cell, 87:1203-14 (1996)  1996

      Immunoblotting (Western), Immunofluorescence8980227 8980227
      The 86-kDa subunit of autoantigen Ku is a somatostatin receptor regulating protein phosphatase-2A activity
      Le Romancer, M., et al
      J Biol Chem, 269:17464-8 (1994)  1994

      Immunoblotting (Western)8021251 8021251