05-1417 | Anti-PTP-PEST Antibody, clone AG25

100 µL  
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      Replacement Information
      Replacement Information05-1417 is a recommended replacement for MAB3739

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IP, ICCMAscitesMonoclonal Antibody
      Catalogue Number05-1417
      DescriptionAnti-PTP-PEST Antibody, clone AG25
      Alternate Names
      • Protein-tyrosine phosphatase G1
      • Tyrosine-protein phosphatase non-receptor type12
      • Protein tyrosine phosphatase, non-receptor type 12
      Background InformationThe protein tyrosine phosphatase PTP-PEST is an cytosolic protein tyrosine phosphatase that is ubiquitously expressed in mammalian tissues. PTP-PEST associates with multiple cytoskeleton and cell adhesion molecules suggesting a regulatory role in controlling cell shape and motility.
      Product Information
      • HeLa cell lysate
      PresentationMouse monoclonal IgG1 ascites containing no preservatives.
      ApplicationAnti-PTP-PEST Antibody, clone AG25 detects level of PTP-PEST & has been published & validated for use in WB, IP & IC.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      • Immunocytochemistry
      Application NotesImmunoprecipitation: Recommended.

      Immunocytochemistry: Recommended.
      Biological Information
      ImmunogenBaculovirus expressed purified human PTP-PEST
      SpecificityRecognizes human PTP-PEST.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. This PTP was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility.
      Gene Symbol
      • PTPN12
      • PTPG1
      • PTP-PEST
      • EC
      UniProt Number
      UniProt SummarySIZE: 780 amino acids; 88120 Da
      SUBUNIT: Interacts with TGFB1I1 (By similarity). Interacts with PSTPIP1.
      DISEASE:SwissProt: Q05209 # Defects in PTPN12 are found in some colon cancers.
      SIMILARITY: SwissProt: Q05209 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. & Contains 1 tyrosine-protein phosphatase domain.
      Molecular Weight~88 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by Western Blot on HeLa lysates.

      Western Blot Analysis: 1:500 dilution of this lot detected PTP-PEST on 10 μg of HeLa lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 1 year from date of receipt.
      Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-PTP-PEST, clone AG25 - 2316816 2316816
      Anti-PTP-PEST, clone AG25 - NG1578603 NG1578603
      Anti-PTP-PEST, clone AG25 - NG1651155 NG1651155
      Anti-PTP-PEST, clone AG25 - NG1698977 NG1698977
      Anti-PTP-PEST, clone AG25 - NG1881305 NG1881305
      Anti-PTP-PEST, clone AG25 -2514997 2514997
      Anti-PTP-PEST, clone AG25 -2788178 2788178
      Anti-PTP-PEST, clone AG25 -2809281 2809281
      Anti-PTP-PEST, clone AG25 Monoclonal Antibody 2949949