05-862 | Anti-Plasminogen/Angiostatin Antibody, clone GMA-013

05-862
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-862
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Plasminogen/Angiostatin Antibody, clone GMA-013
      References
      Product Information
      FormatPurified
      Applications
      ApplicationThis Anti-Plasminogen/Angiostatin Antibody, clone GMA-013 is validated for use in ELISA, WB for the detection of Plasminogen/Angiostatin.
      Key Applications
      • ELISA
      • Western Blotting
      Biological Information
      ImmunogenPurified human plasminogen
      Cloneclone GMA-013
      HostMouse
      SpecificityPlasminogen (kringles 1-3)
      IsotypeIgM
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryPlasminogen (PLG) is a circulating zymogen that is converted to the active enzyme plasmin by cleavage of the peptide bond between arg560 and val561, which is mediated by urokinase (PLAU; MIM 191840) and tissue plasminogen activator (TPA, PLAT; MIM 173370). The main function of plasmin is to dissolve fibrin (see, e.g., FGA, MIM 134820) clots. Plasmin, like trypsin, belongs to the family of serine proteinases (Miyata et al., 1982 [PubMed 6216475]; Forsgren et al., 1987 [PubMed 3030813]).[supplied by OMIM]
      Gene Symbol
      • PLG
      • DKFZp779M0222
      • plasminogen
      Purification MethodDEAE purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P00747 # Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.
      SIZE: 810 amino acids; 90569 Da
      SUBUNIT: Interacts with AMOT and CSPG4 (also true for angiostatin).
      SUBCELLULAR LOCATION: Secreted.
      TISSUE SPECIFICITY: Present in plasma and many other extracellular fluids. It is synthesized in the kidney.
      DOMAIN: SwissProt: P00747 Kringle domains mediate interaction with CSPG4.
      PTM: N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity). & In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide.
      DISEASE: "SwissProt: P00747 # Defects in PLG are a cause of thrombophilia [MIM:188050]; a form of recurrent thrombosis. & Defects in PLG may be associated with ligneous conjunctivitis [MIM:217090]. Ligneous conjunctivitis is an unusual and rare form of chronic conjunctivitis, characterized by chronic tearing and redness of the conjunctivae. Initially, pseudomembranes form on the palpebral surfaces which then progress to thick nodular masses that replace the normal mucosa. Because the pseudomembranes have a woodlike consistency, the disease is termed ""ligneous"" conjunctivitis. The disease may be associated with pseudomembranous lesions of other mucous membranes in the mouth, nasopharynx, trachea, and female genital tract."
      SIMILARITY: Belongs to the peptidase S1 family. Plasminogen subfamily. & Contains 5 kringle domains. & Contains 1 PAN domain. & Contains 1 peptidase S1 domain.
      MISCELLANEOUS: Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.
      Molecular WeightMr 88kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on human plasminogen
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditionsstable 2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Plasminogen/Angiostatin, clone GMA-013 (mouse monoclonal IgM) - 2148261 2148261
      Anti-Plasminogen/Angiostatin, clone GMA-013 (mouse monoclonal IgM) 3009785
      Anti-Plasminogen/Angiostatin, clone GMA-013 (mouse monoclonal IgM) - 2002732 2002732
      Anti-Plasminogen/Angiostatin, clone GMA-013 (mouse monoclonal IgM) - 2274285 2274285
      Anti-Plasminogen/Angiostatin, clone GMA-013 (mouse monoclonal IgM) - 2280438 2280438
      Anti-Plasminogen/Angiostatin, clone GMA-013 - 2426980 2426980
      Anti-Plasminogen/Angiostatin, clone GMA-013 - 27180 27180
      Anti-Plasminogen/Angiostatin, clone GMA-013 -2521304 2521304
      Anti-Plasminogen/Angiostatin, clone GMA-013 -2749228 2749228
      Anti-Plasminogen/Angiostatin, clone GMA-013 -2752711 2752711

      References

      Reference overviewPub Med ID
      Angiostatin and anti-angiogenic therapy in human disease.
      Wahl, Miriam L, et al.
      Recent Prog. Horm. Res., 59: 73-104 (2004)  2004

      Show Abstract
      14749498 14749498