05-878 | Anti-Protein C Antibody, clone GMA-093

05-878
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-878
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Protein C Antibody, clone GMA-093
      References
      Product Information
      FormatPurified
      Applications
      ApplicationAnti-Protein C Antibody, clone GMA-093 detects level of Protein C & has been published & validated for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Biological Information
      ImmunogenPurified human Protein C
      CloneGMA-093
      HostMouse
      SpecificityProtein C
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PROC
      • PROC1
      Purification MethodDEAE purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P04070 # Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.
      SIZE: 461 amino acids; 52071 Da
      SUBUNIT: Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin.
      TISSUE SPECIFICITY: Plasma; synthesized in the liver.
      PTM: The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium. & Partial (70%) N-glycosylation of Asn-371 with an atypical N- X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not glycosylated at Asn- 371, is beta.
      DISEASE: "SwissProt: P04070 # Defects in PROC are the cause of protein C deficiency (PROC deficiency) [MIM:176860]. PROC deficiency is an important risk factor for hereditary thrombophilia [MIM:188050], a multifactorial trait characterized by recurrent thrombosis and abnormal platelet aggregation in response to various agents. A severe recessive form of PROC deficiency results in neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare and has an incidence of about 1:500,000 live births. Most cases of PROC deficiency have had a quantitative defect in the protein C molecule. PROC deficiency with a mutation that causes diminished synthesis of protein has been referred to as type I and that with synthesis of a dysfunctional molecule as type II."SIMILARITY:SwissProt: P04070 ## Belongs to the peptidase S1 family. & Contains 2 EGF-like domains. & Contains 1 Gla (gamma-carboxy-glutamate) domain. & Contains 1 peptidase S1 domain.
      MISCELLANEOUS: Calcium also binds, with stronger affinity to another site, beyond the GLA domain. This GLA-independent binding site is necessary for the recognition of the thrombin- thrombomodulin complex.
      Molecular Weightnon-reduced, Mr 62kDa, reduced , Mr 41kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on human Protein C
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditionsstable 2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications