07-1392 | Anti-Rab40C Antibody

07-1392
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IHCRbUnpurifiedPolyclonal Antibody
      Description
      Catalogue Number07-1392
      DescriptionAnti-Rab40C Antibody
      Alternate Names
      • RAB40C, member RAS oncogene family
      • RAR (RAS like GTPASE) like
      • RAR like
      • RAS-like GTPase
      • RAS-like, family 8, member C
      • Rar-like protein
      • Ras-like protein family member 8C
      • SOCS box-containing protein RAR3
      Background InformationThe Rab family of proteins are a member of the Ras superfamily of small G-Proteins. At least 60 isoforms have been identified. These GTPases are primarily involved in regulating distinct steps in vesicle trafficking by regulating the dynamic assembly and disassembly of the multi-protein scaffolds that are involved in vesicle trafficking. In its active, GTP-bound state, the Rab protein recruits effector proteins to the membrane. Rabs lack intrinsic GTPase hydrolysis activity and thus rely on guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs) to regulate their activity. Through these effectors, they regulate vessicle formation and movement. Rab4 and Rab11 are involved in internalization, sorting and transport to lysosomes or recycling of several membrane proteins, including GPCRs, GLUT-4, Aquaporin-2 or the H+/K+ ATPase.
      References
      Product Information
      FormatUnpurified
      PresentationRabbit Serum
      Applications
      ApplicationUse Anti-Rab40C Antibody (Rabbit Polyclonal Antibody) validated in WB, IHC to detect Rab40C also known as RAS-like GTPase, SOCS box-containing protein RAR3.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blot Analysis :
      Immunohistochemistry Analysis:
      Immunohistochemistry (IHC) staining of mouse epithelium cells during lung development. Antibody was used at a 1:1,000 dilution and stained overnight at 4°C. 10X amplification.
      Biological Information
      ImmunogenFull-length His-tagged Rab40C recombinant protein (mouse).
      HostRabbit
      SpecificityDetects Rab40C
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteHuman, Mouse, and Rat. Other species have not been tested.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • RARL
      • RASL8C
      • RAB40C
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFunction: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
      Pathway: Protein modification; protein ubiquitination.
      Subunit structure: Component of the probable SCF-like ECS(RAB40C) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and RAB40C. Interacts with CUL5, RNF7, TCEB1 and TCEB2.
      Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic sidePotential.
      Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes By similarity.
      Sequence similarities: Belongs to the small GTPase superfamily. Rab family.
      Contains 1 SOCS box domain
      Molecular Weight31 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceWestern Blot Analysis:
      This lot detected Rab40C at 1:1,000 dilution in Rat lung lysate resolved via SDS-PAGE and transferred to PVDF
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt. Store at -80°C for longer term storage. Avoid repeated freeze/thaws.
      Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      Anti-Rab40C - NG1572356 NG1572356

      References

      Reference overviewPub Med ID
      Large-scale profiling of Rab GTPase trafficking networks: the membrome.
      Gurkan, Cemal, et al.
      Mol. Biol. Cell, 16: 3847-64 (2005)  2005

      15944222 15944222
      Vesicle transport in oligodendrocytes: probable role of Rab40c protein.
      Rodriguez-Gabin, A G, et al.
      J. Neurosci. Res., 76: 758-70 (2004)  2004

      Show Abstract
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