07-419 | Anti-SHP-1/SHPTP-1 Antibody

07-419
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIP, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number07-419
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-SHP-1/SHPTP-1 Antibody
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide
      Applications
      ApplicationThis Anti-SHP-1/SHPTP-1 Antibody is validated for use in IP, WB for the detection of SHP-1/SHPTP-1.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenFull-length glutathione transferase SHP-1 fusion protein, purified from bacteria
      HostRabbit
      SpecificitySHP1
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.
      Gene Symbol
      • PTPN6
      • HCP
      • SH-PTP1
      • PTP-1C
      • SHP1
      • SHP-1L
      • PTP1C
      • HCPH
      • SHP-1
      • HPTP1C
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P29350 # Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.
      SIZE: 595 amino acids; 67561 Da
      SUBUNIT: Monomer. Interacts with MTUS1 (By similarity). Binds PTPNS1, LILRB1 and LILRB2. Interacts with FCRL2, CD300LF and CD84.
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity). Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity).
      TISSUE SPECIFICITY: Isoform 1 is expressed in hematopoietic cells while isoform 2 is expressed in non-hematopoietic cells.
      PTM: Phosphorylated on serine and tyrosine residues.
      SIMILARITY: SwissProt: P29350 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. & Contains 2 SH2 domains. & Contains 1 tyrosine-protein phosphatase domain.
      Molecular Weight65kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot in RIPA lysates from human A431 carcinoma cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at 2-8°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-SHP-1 (rabbit polyclonal IgG) - 2135174 2135174
      Anti-SHP-1 (rabbit polyclonal IgG) 2988101
      Anti-SHP-1 (rabbit polyclonal IgG) 3059106
      Anti-SHP-1 (rabbit polyclonal IgG) - 2040530 2040530
      Anti-SHP-1 (rabbit polyclonal IgG) - 2322527 2322527
      Anti-SHP-1 (rabbit polyclonal IgG) - JBC1945032 JBC1945032
      Anti-SHP-1 - 2530023 2530023
      Anti-SHP-1 - DAM1552035 DAM1552035
      Anti-SHP-1 - DAM1606760 DAM1606760
      Anti-SHP-1 - DAM1692634 DAM1692634

      References

      Reference overviewApplicationPub Med ID
      Regulation of somatostatin receptor 4-mediated cytostatic effects by CD26 in malignant pleural mesothelioma.
      Yamamoto, J; Ohnuma, K; Hatano, R; Okamoto, T; Komiya, E; Yamazaki, H; Iwata, S; Dang, NH; Aoe, K; Kishimoto, T; Yamada, T; Morimoto, C
      British journal of cancer  110  2232-45  2014

      Show Abstract
      24743707 24743707
      A hallmark of immunoreceptor, the tyrosine-based inhibitory motif ITIM, is present in the G protein-coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism.
      Thierry Voisin, Aadil El Firar, Christiane Rouyer-Fessard, Valérie Gratio, Marc Laburthe
      The FASEB journal : official publication of the Federation of American Societies for Experimental Biology  22  1993-2002  2008

      Show Abstract
      18198212 18198212
      An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells.
      Ming-Can Yu, Liu-Li Su, Lin Zou, Ye Liu, Na Wu, Ling Kong, Zi-Heng Zhuang, Lei Sun, Hai-Peng Liu, Jun-Hao Hu, Dangsheng Li, Jack L Strominger, Jing-Wu Zang, Gang Pei, Bao-Xue Ge
      Nature immunology  9  898-907  2008

      Show Abstract
      18604210 18604210
      Erythropoietin induces sustained phosphorylation of STAT5 in primitive but not definitive erythrocytes generated from mouse embryonic stem cells.
      Kazue Tsuji-Takayama, Takeshi Otani, Toshiya Inoue, Shuji Nakamura, Ryuichi Motoda, Masayoshi Kibata, Kunzo Orita
      Experimental hematology  34  1323-32  2006

      Show Abstract
      16982325 16982325
      Molecular basis of the recruitment of the SH2 domain-containing inositol 5-phosphatases SHIP1 and SHIP2 by fcgamma RIIB.
      Bruhns, P, et al.
      J. Biol. Chem., 275: 37357-64 (2000)  2000

      Show Abstract
      11016922 11016922
      The phosphotyrosine phosphatase PTP1D, but not PTP1C, is an essential mediator of fibroblast proliferation induced by tyrosine kinase and G protein-coupled receptors.
      Rivard, N, et al.
      J. Biol. Chem., 270: 11017-24 (1995)  1995

      Show Abstract
      Immunoprecipitation, Phosphatase Assay7537742 7537742

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies