06-891 | Anti-SMRTe Antibody

06-891
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MICC, WB, ChIPRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-891
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-SMRTe Antibody
      Background InformationSMRT is 1495 amino acids and contains an 8 amino acid sequence that is not present in SMRTe (SMRT-extended), which contains 2514 amino acids. SMRTe contains an N-terminal sequence spanning over 1,000 amino acids that is not present in SMRT, but that shows significant similarity with N-CoR. SMRTe expression is regulated during cell cycle progression, suggesting a role for SMRTe in the regulation of cycle-specific gene expression in diverse signaling pathways.
      References
      Product Information
      FormatPurified
      Control
      • Mouse brain nuclear extract
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      Applications
      ApplicationAnti-SMRTe Antibody is a high quality Rabbit Polyclonal Antibody for the detection of SMRTe & has been validated in ChIP, ICC & WB.
      Key Applications
      • Immunocytochemistry
      • Western Blotting
      • Chromatin Immunoprecipitation (ChIP)
      Biological Information
      ImmunogenGST fusion-protein corresponding to residues 1146-1349 of human SMRTe
      HostRabbit
      SpecificitySMRT isoforms
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NCOR2
      • SMRTE
      • TRAC-1
      • CTG26
      • SMRTe
      • TNRC14
      • SMRT
      • TRAC1
      • SMAP270
      • SMRTE-tau
      • TRAC
      • N-CoR2
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9Y618 # Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.
      SIZE: 2517 amino acids; 274034 Da
      SUBUNIT: Interacts with HDAC7 (By similarity). Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. The SRMT isoform interacts with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with CBFA2T3.
      SUBCELLULAR LOCATION: Nucleus.
      TISSUE SPECIFICITY: Ubiquitous. High levels of expression are detected in lung, spleen and brain.
      DOMAIN: SwissProt: Q9Y618 The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor- interacting domains that are divided in two separate interaction domains (ID1 and ID2). & The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.
      SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family. & Contains 2 SANT domains.
      Molecular Weight270kDa, 180kDa and 80kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on nuclear fraction from murine brain
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-SMRTe - 2135171 2135171
      Anti-SMRTe - 17909 17909
      Anti-SMRTe - 2044108 2044108
      Anti-SMRTe - 2073115 2073115
      Anti-SMRTe - 2207270 2207270
      Anti-SMRTe - 2297228 2297228
      Anti-SMRTe - 23043 23043
      Anti-SMRTe - 26566 26566
      Anti-SMRTe - 33510 33510
      Anti-SMRTe - 33510A 33510A

      References

      Reference overviewApplicationPub Med ID
      NCoR1 and SMRT play unique roles in thyroid hormone action in vivo.
      Shimizu, H; Astapova, I; Ye, F; Bilban, M; Cohen, RN; Hollenberg, AN
      Molecular and cellular biology  35  555-65  2015

      Show Abstract
      25421714 25421714
      Rescue of a primary myelofibrosis model by retinoid-antagonist therapy.
      Hong, SH; Dvorak-Ewell, M; Stevens, HY; Barish, GD; Castro, GL; Nofsinger, R; Frangos, JA; Shoback, D; Evans, RM
      Proceedings of the National Academy of Sciences of the United States of America  110  18820-5  2013

      Show Abstract
      24191050 24191050
      Nuclear corepressors mediate the repression of phospholipase A2 group IIa gene transcription by thyroid hormone.
      Sharma, P; Thakran, S; Deng, X; Elam, MB; Park, EA
      The Journal of biological chemistry  288  16321-33  2013

      Show Abstract
      Western Blotting23629656 23629656
      Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes.
      Caron, S; Huaman Samanez, C; Dehondt, H; Ploton, M; Briand, O; Lien, F; Dorchies, E; Dumont, J; Postic, C; Cariou, B; Lefebvre, P; Staels, B
      Molecular and cellular biology  33  2202-11  2013

      Show Abstract
      Western Blotting23530060 23530060
      The Stat3/GR Interaction Code: Predictive Value of Direct/Indirect DNA Recruitment for Transcription Outcome.
      David Langlais,Catherine Couture,Aurélio Balsalobre,Jacques Drouin
      Molecular cell  47  2012

      Show Abstract
      22633955 22633955
      TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells.
      Takahashi, H; Kanno, T; Nakayamada, S; Hirahara, K; Sciumè, G; Muljo, SA; Kuchen, S; Casellas, R; Wei, L; Kanno, Y; O'Shea, JJ
      Nature immunology  13  587-95  2012

      Show Abstract
      22544395 22544395
      Identification of location and kinetically defined mechanism of cofactors and reporter genes in the cascade of steroid-regulated transactivation.
      Blackford, JA; Guo, C; Zhu, R; Dougherty, EJ; Chow, CC; Simons, SS
      The Journal of biological chemistry  287  40982-95  2012

      Show Abstract
      Western Blotting23055525 23055525
      GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response.
      Venteclef, N; Jakobsson, T; Ehrlund, A; Damdimopoulos, A; Mikkonen, L; Ellis, E; Nilsson, LM; Parini, P; Jänne, OA; Gustafsson, JA; Steffensen, KR; Treuter, E
      Genes & development  24  381-95  2010

      Show Abstract
      20159957 20159957
      Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture.
      Safi, R; Muramoto, GG; Salter, AB; Meadows, S; Himburg, H; Russell, L; Daher, P; Doan, P; Leibowitz, MD; Chao, NJ; McDonnell, DP; Chute, JP
      Molecular endocrinology (Baltimore, Md.)  23  188-201  2009

      Show Abstract
      19106195 19106195
      Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer.
      Fernández-Majada, V; Aguilera, C; Villanueva, A; Vilardell, F; Robert-Moreno, A; Aytés, A; Real, FX; Capella, G; Mayo, MW; Espinosa, L; Bigas, A
      Proceedings of the National Academy of Sciences of the United States of America  104  276-81  2007

      Show Abstract Full Text Article
      17190815 17190815

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies