06-588 | Anti-STAT5A/B Antibody

06-588
250 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R, ShEMSARbSerumPolyclonal Antibody
      Description
      Catalogue Number06-588
      Replaces04-1016
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-STAT5A/B Antibody
      References
      Product Information
      FormatSerum
      Presentationwhole rabbit antiserum containing 0.05% sodium azide
      Applications
      ApplicationDetect STAT5A/B also known as signal transducer & activator of transcription 5A/B with Anti-STAT5A/B Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in EMSA.
      Key Applications
      • Electrophoretic Mobility Shift Assay
      Biological Information
      Immunogenpeptide (CQELQKKAEHQVGEDG), corresponding to amino acids 66-80 of human STAT5 A and B
      HostRabbit
      SpecificitySTAT5A and B
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      • Sheep
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
      Gene Symbol
      • STAT5A
      • MGF
      • STAT5
      Purification MethodAntiserum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P42229 # Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.
      SIZE: 794 amino acids; 90647 Da
      SUBUNIT: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 and SOCS7.
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
      PTM: Tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL- 15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin. Tyrosine phosphorylation is required for DNA- binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).
      SIMILARITY: SwissProt: P42229 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.
      Molecular Weight90-95 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by Supershift
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size250 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-STAT5 A/B (rabbit antiserum) - 2448445 2448445
      Anti-STAT5 A/B (rabbit antiserum) - 2273156 2273156
      Anti-STAT5 A/B - 2044801 2044801
      Anti-STAT5 A/B - DAM1487552 DAM1487552
      Anti-STAT5 A/B - DAM1661055 DAM1661055
      Anti-STAT5 A/B -2614572 2614572
      Anti-STAT5A/B - 16672 16672
      Anti-STAT5A/B - 21576 21576

      References

      Reference overviewApplicationPub Med ID
      A Non-ATP-Competitive Dual Inhibitor of JAK2 and BCR-ABL Kinases: Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition.
      Jatiani, SS; Cosenza, SC; Reddy, MV; Ha, JH; Baker, SJ; Samanta, AK; Olnes, MJ; Pfannes, L; Sloand, EM; Arlinghaus, RB; Reddy, EP
      Genes & cancer  1  331-45  2010

      Show Abstract
      Western Blotting20717479 20717479
      A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of gammaC gene oncogenicity.
      Linda Scobie,Ralph D Hector,Louise Grant,Margaret Bell,Anne A Nielsen,Sharon Meikle,Adrian Philbey,Adrain Philbey,Adrian J Thrasher,Adrain J Thrasher,Ewan R Cameron,Karen Blyth,James C Neil
      Molecular therapy : the journal of the American Society of Gene Therapy  17  2009

      Show Abstract Full Text Article
      19337236 19337236
      Novel role for STAT-5B in the regulation of Hsp27-FGF-2 axis facilitating thrombin-induced vascular smooth muscle cell growth and motility.
      Cao, H; Dronadula, N; Rizvi, F; Li, Q; Srivastava, K; Gerthoffer, WT; Rao, GN
      Circulation research  98  913-22  2006

      Show Abstract
      16527988 16527988
      Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells.
      Dubois, S; Shou, W; Haneline, LS; Fleischer, S; Waldmann, TA; Müller, JR
      Proceedings of the National Academy of Sciences of the United States of America  100  14169-74  2003

      Show Abstract
      14605212 14605212
      Convergence of progesterone and epidermal growth factor signaling in breast cancer. Potentiation of mitogen-activated protein kinase pathways
      Lange, C. A., et al
      J Biol Chem, 273:31308-16 (1998)  1998

      Immunoprecipitation, Immunoblotting (Western)9813039 9813039
      The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15.
      Lin, J X, et al.
      Immunity, 2: 331-9 (1995)  1995

      Show Abstract
      7719938 7719938
      Characterization of the human interleukin-2 receptor beta-chain gene promoter: regulation of promoter activity by ets gene products.
      Lin, J X, et al.
      Mol. Cell. Biol., 13: 6201-10 (1993)  1993

      Show Abstract
      8413220 8413220

      Technical Info

      Title
      JAK/STAT Signaling Research Focus

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies