06-913 | Anti-Sin3A Antibody

06-913
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-913
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Sin3A Antibody
      References
      Product Information
      FormatPurified
      Presentation0.07M Tris-glycine, pH 7.2, 0.105M NaCl, 0.035% sodium azide containing 30% glycerol
      Applications
      ApplicationDetect Sin3A with Anti-Sin3A Antibody (Rabbit Polyclonal Antibody), that has been shown to work in WB.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogenpeptide (KRRLDDQESPVYAAQQRR-C) corresponding to amino acids 2-18 of mouse mSin3A
      HostRabbit
      SpecificitySin3A
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.
      Gene Symbol
      • SIN3A
      • KIAA0700
      • FLJ90319
      • DKFZP434K2235
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q96ST3 # Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3A to DNA. Acts as a corepressor for REST (By similarity).
      SIZE: 1273 amino acids; 145175 Da
      SUBUNIT: Interacts with MBD2, SAP30, NCOR1 and SDS3 (By similarity). Interacts with MXI1, MAD, DACH1, HCFC1, SETDB1 and SFPQ. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with MAD3 and MAD4. Interacts with REST (By similarity). Interacts with BRMS1L, SAP130, SUDS3/SAP45, ARID4B/SAP180 and HDAC2. Interacts with SAP30L.
      SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Note=Recruited to the nucleolus by SAP30L.
      SIMILARITY: SwissProt: Q96ST3 ## Contains 3 PAH (paired amphipathic helix) repeats.
      Molecular Weight150kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from Hela nuclear extract
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Sin3A (rabbit polyclonal IgG) - DAM1780372 DAM1780372
      Anti-Sin3A - 18259 18259
      Anti-Sin3A - 30090 30090
      Anti-Sin3A - DAM1661062 DAM1661062
      Anti-Sin3A - JBC1863984 JBC1863984

      References

      Reference overviewApplicationSpeciesPub Med ID
      RNA-sequencing analysis of high glucose-treated monocytes reveals novel transcriptome signatures and associated epigenetic profiles.
      Miao, F; Chen, Z; Zhang, L; Wang, J; Gao, H; Wu, X; Natarajan, R
      Physiological genomics  45  287-99  2013

      Show Abstract
      Human23386205 23386205
      Levetiracetam enhances p53-mediated MGMT inhibition and sensitizes glioblastoma cells to temozolomide.
      Bobustuc, GC; Baker, CH; Limaye, A; Jenkins, WD; Pearl, G; Avgeropoulos, NG; Konduri, SD
      Neuro-oncology  12  917-27  2010

      Show Abstract Full Text Article
      20525765 20525765
      Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression.
      Yamaguchi, T; Cubizolles, F; Zhang, Y; Reichert, N; Kohler, H; Seiser, C; Matthias, P
      Genes & development  24  455-69  2010

      Show Abstract Full Text Article
      20194438 20194438
      Analysis of transcription factor interactions in osteoblasts using competitive chromatin immunoprecipitation.
      Roca, H; Franceschi, RT
      Nucleic acids research  36  1723-30  2008

      Show Abstract
      18263612 18263612
      The retinoblastoma protein regulates pericentric heterochromatin.
      Isaac, CE; Francis, SM; Martens, AL; Julian, LM; Seifried, LA; Erdmann, N; Binné, UK; Harrington, L; Sicinski, P; Bérubé, NG; Dyson, NJ; Dick, FA
      Molecular and cellular biology  26  3659-71  2006

      Show Abstract Full Text Article
      Immunofluorescence16612004 16612004
      Sexually dimorphic expression of co-repressor Sin3A in mouse kidneys.
      Jun Xu, Arthur P Arnold, Jun Xu, Arthur P Arnold
      Endocrine research  31  111-9  2005

      Show Abstract
      16355490 16355490
      Transcription factor interactions and chromatin modifications associated with p53-mediated, developmental repression of the alpha-fetoprotein gene.
      Nguyen, TT; Cho, K; Stratton, SA; Barton, MC
      Molecular and cellular biology  25  2147-57  2005

      Show Abstract
      Mouse15743813 15743813
      Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns
      Craig, J. M., et al
      Hum Mol Genet, 12:3109-21 (2003)  2003

      Immunoblotting (Western)14519686 14519686
      Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo.
      Kadosh, D and Struhl, K
      Mol. Cell. Biol., 18: 5121-7 (1998)  1998

      Show Abstract
      9710596 9710596
      The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression.
      Dhordain, P, et al.
      Nucleic Acids Res., 26: 4645-51 (1998)  1998

      Show Abstract
      9753732 9753732

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies