06-900 | Anti-SynGAP Antibody

06-900
100 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RICC, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-900
      Replaces04-1071
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-SynGAP Antibody
      Background InformationSilent synapses, or excitatory synapses that lack functional -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), are thought to be critical for regulation of neuronal circuits and synaptic plasticity. SynGAP, an excitatory synapse-specific RasGAP, regulates AMPAR trafficking, silent synapse number, and excitatory synaptic transmission in hippocampal and cortical cultured neurons. Over expression of SynGAP in neurons results in a remarkable depression of AMPAR-mediated miniature excitatory postsynaptic currents, a significant reduction in synaptic AMPAR surface expression, and a decrease in the insertion of AMPARs into the plasma membrane. Synaptic transmission is increased in neurons from SynGAP knockout mice as well as in neuronal cultures treated with SynGAP small interfering RNA.
      References
      Product Information
      FormatPurified
      PresentationPurified in PBS with 0.05% NaN3 and 30% Glycerol
      Applications
      ApplicationAnti-SynGAP Antibody detects level of SynGAP & has been published & validated for use in IC & WB.
      Key Applications
      • Immunocytochemistry
      • Western Blotting
      Application NotesImmunocytochemistry: 0.1 µg/mL has been reported to immunostain SynGAP in neuron cultures fixed with 4% paraformaldehyde, 4% sucrose and perme-abilized with 0.1% Triton X-100 (2).
      Biological Information
      Immunogenpeptide (KRLLDAQRGSFPPWVQQTRV) corresponding to amino acids 1274-1293 of rat SynGAP-a
      HostRabbit
      SpecificitySynGAP
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SYNGAP1
      • RASA5
      • DKFZp761G1421
      • OTTHUMP00000064825
      • SYNGAP
      • RASA1
      • KIAA1938
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q96PV0 # Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR- mediated miniature excitatory postsynaptic currents. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).
      SIZE: 1343 amino acids; 148284 Da
      SUBUNIT: Interacts CAMK2A and CAMK2B (By similarity). Interacts with MPDZ.
      PTM: Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption (By similarity).
      SIMILARITY: SwissProt: Q96PV0 ## Contains 1 C2 domain. & Contains 1 PH domain. & Contains 1 Ras-GAP domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-SynGAP 2484074
      Anti-SynGAP - NG1508373 NG1508373
      Anti-SynGAP -2518475 2518475
      Anti-SynGAP -2568284 2568284
      Anti-SynGAP -2591921 2591921
      Anti-SynGAP -2649125 2649125
      Anti-SynGAP -2801050 2801050

      References

      Reference overviewApplicationPub Med ID
      MET receptor tyrosine kinase controls dendritic complexity, spine morphogenesis, and glutamatergic synapse maturation in the hippocampus.
      Qiu, S; Lu, Z; Levitt, P
      The Journal of neuroscience : the official journal of the Society for Neuroscience  34  16166-79  2014

      Show Abstract
      Immunohistochemistry25471559 25471559
      SynGAP isoforms exert opposing effects on synaptic strength.
      McMahon, AC; Barnett, MW; O'Leary, TS; Stoney, PN; Collins, MO; Papadia, S; Choudhary, JS; Komiyama, NH; Grant, SG; Hardingham, GE; Wyllie, DJ; Kind, PC
      Nature communications  3  900  2012

      Show Abstract
      Western Blotting22692543 22692543
      Characterization of a novel synGAP isoform, synGAP-beta.
      Li, W; Okano, A; Tian, QB; Nakayama, K; Furihata, T; Nawa, H; Suzuki, T
      The Journal of biological chemistry  276  21417-24  2001

      Show Abstract
      11278737 11278737