05-946 | Anti-Trophinin Antibody, clone 3-11

05-946
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MIP, WB, IHCMCulture SupernatantMonoclonal Antibody
      Description
      Catalogue Number05-946
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Trophinin Antibody, clone 3-11
      References
      Product Information
      FormatCulture Supernatant
      Applications
      ApplicationAnti-Trophinin Antibody, clone 3-11 detects level of Trophinin & has been published & validated for use in IP, WB, IH.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      • Immunohistochemistry
      Biological Information
      ImmunogenKLH-conjugated, synthetic peptide corresponding to amino acids 1319-1327 (SIVGFSGGP-C) of human Trophinin (MAGE-D3)
      Cloneclone 3-11
      HostMouse
      SpecificityTrophinin (MAGE-D3)
      IsotypeIgM
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a membrane protein that mediates apical cell adhesion between trophoblastic cells and luminal epithelial cells of the endometrium and is implicated in the initial attachment during the process of embryo implantation. This gene is related to the MAGED gene family by sequence similarity and chromosome location. Multiple alternatively spliced transcript variants have been found for this gene; however, the full-length nature of some variants has not been defined.
      Gene Symbol
      • TRO
      • KIAA1114
      • MAGE-d3
      • MAGE-D3
      • Trophinin
      • MAGED3
      • magphinin
      • trophinin
      Purification MethodCell culture supernatant
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q12816 # Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion.
      SIZE: 1431 amino acids; 143716 Da
      SUBUNIT: Directly binds bystin, and indirectly tastin.
      TISSUE SPECIFICITY: Strong expression at implantation sites. Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the level decreased and then disappeared from placental villi. Also found in macrophages.
      SIMILARITY: SwissProt: Q12816 ## Contains 1 MAGE domain.
      Molecular Weight69 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot in RIPA lysates from HT-H cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Trophinin, clone 3-11 (mouse monoclonal IgM) 2868349
      Anti-Trophinin, clone 3-11 (mouse monoclonal IgM) 2971804
      Anti-Trophinin, clone 3-11 (mouse monoclonal IgM) 2898881
      Anti-Trophinin, clone 3-11 (mouse monoclonal IgM) 2885170
      Anti-Trophinin, clone 3-11 (mouse monoclonal IgM) 2950535
      Anti-Trophinin, clone 3-11 - 30542 30542
      Anti-Trophinin, clone 3-11 -2703757 2703757
      Anti-Trophinin, clone 3-11 -2709670 2709670
      Anti-Trophinin, clone 3-11 -2769547 2769547

      References

      Reference overviewPub Med ID
      The MAGE proteins: emerging roles in cell cycle progression, apoptosis, and neurogenetic disease.
      Barker, Philip A and Salehi, Amir
      J. Neurosci. Res., 67: 705-12 (2002)  2002

      11891783 11891783
      Cancer/testis antigens: structural and immunobiological properties.
      Kirkin, Alexei F, et al.
      Cancer Invest., 20: 222-36 (2002)  2002

      Show Abstract
      11901543 11901543
      Recent molecular approaches to elucidate the mechanism of embryo implantation: trophinin, bystin, and tastin as molecules involved in the initial attachment of blastocysts to the uterus in humans.
      Aoki, R and Fukuda, M N
      Semin. Reprod. Med., 18: 265-71 (2000)  2000

      11299965 11299965