05-860 | Anti-Vitronectin Antibody, clone GMA-900

05-860
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-860
      Replaces04-1108
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Vitronectin Antibody, clone GMA-900
      References
      Product Information
      FormatPurified
      Applications
      ApplicationDetect Vitronectin using this Anti-Vitronectin Antibody, clone GMA-900 validated for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Biological Information
      ImmunogenPurified human vitronectin
      CloneGMA-900
      HostMouse
      SpecificityVitronectin
      IsotypeIgG2a
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond.
      Gene Symbol
      • VTN
      • S-protein
      • VNT
      • VN
      • epibolin
      • V75
      Purification MethodDEAE purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P04004 # Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
      SIZE: 478 amino acids; 54306 Da
      SUBUNIT: Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1 and insulin.
      SUBCELLULAR LOCATION: Secreted, extracellular space.
      TISSUE SPECIFICITY: Plasma.
      DOMAIN: SwissProt: P04004 The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
      PTM: Sulfated on 2 tyrosine residues. & N- and O-glycosylated (By similarity). & Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading. & It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.SIMILARITY: Contains 4 hemopexin-like domains. & Contains 1 SMB (somatomedin-B) domain.
      Molecular WeightMr 54kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on victronectin
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditionsstable 2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Vitronectin, clone GMA-900 (mouse monoclonal IgG2a) - 2272693 2272693
      Anti-Vitronectin, clone GMA-900 - 27178 27178
      Anti-Vitronectin, clone GMA-900 -2628277 2628277

      References

      Reference overviewPub Med ID
      Caught in the matrix: how vitronectin controls neuronal differentiation.
      Wechsler-Reya, R J
      Trends Neurosci., 24: 680-2 (2001)  2001

      Show Abstract
      11718852 11718852
      Vitronectin.
      Schvartz, I, et al.
      Int. J. Biochem. Cell Biol., 31: 539-44 (1999)  1999

      Show Abstract
      10399314 10399314

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies