06-765 | Anti-mGluR4a Antibody

06-765
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-765
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-mGluR4a Antibody
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      Applications
      ApplicationAnti-mGluR4a Antibody is an antibody against mGluR4a for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogenpeptide (CGGLETPALATKQTYVTYTNHAI) corresponding to amino acids 893-912 of the C-terminus of rat brain mGluR4a
      HostRabbit
      SpecificitymGluR4a; will not detect mGlur4b
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryL-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
      Gene Symbol
      • GRM4
      • mGlu4
      • MGLUR4
      • mGluR4
      • GPRC1D
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q14833 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.
      SIZE: 912 amino acids; 101868 Da
      SUBUNIT: Interacts with PRKCABP (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.
      SIMILARITY: SwissProt: Q14833 ## Belongs to the G-protein coupled receptor 3 family.
      Molecular Weight100-110kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on rat brain microsomal preparation
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-mGluR4a (rabbit polyclonal IgG) - 06-765 06-765
      Anti-mGluR4a - 16969 16969
      Anti-mGluR4a - 22930 22930
      Anti-mGluR4a - 32829 32829

      References

      Reference overviewApplicationPub Med ID
      Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.
      Yin, S; Noetzel, MJ; Johnson, KA; Zamorano, R; Jalan-Sakrikar, N; Gregory, KJ; Conn, PJ; Niswender, CM
      The Journal of neuroscience : the official journal of the Society for Neuroscience  34  79-94  2014

      Show Abstract
      Immunoprecipitation24381270 24381270
      Changes in midbrain pain receptor expression, gait and behavioral sensitivity in a rat model of radiculopathy.
      Hwang, PY; Allen, KD; Shamji, MF; Jing, L; Mata, BA; Gabr, MA; Huebner, JL; Kraus, VB; Richardson, WJ; Setton, LA
      The open orthopaedics journal  6  383-91  2012

      Show Abstract
      22962568 22962568
      Molecular determinants of high affinity binding to group III metabotropic glutamate receptors
      Rosemond, E., et al
      J Biol Chem, 277:7333-40 (2002)  2002

      Immunoblotting (Western)11744707 11744707
      Mapping of calmodulin and Gbetagamma binding domains within the C-terminal region of the metabotropic glutamate receptor 7A.
      El Far, O, et al.
      J. Biol. Chem., 276: 30662-9 (2001)  2001

      Show Abstract
      Immunoblotting (Western)11395497 11395497
      Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells.
      Wu, S, et al.
      Brain Res. Mol. Brain Res., 53: 88-97 (1998)  1998

      Show Abstract
      9473604 9473604
      Localization of mGluR4 protein in the rat cerebral cortex and hippocampus.
      Phillips, T, et al.
      Neuroreport, 8: 3349-54 (1997)  1997

      Show Abstract
      9351670 9351670
      Neuroprotective effects of group III mGluR in traumatic neuronal injury.
      Faden, A I, et al.
      J. Neurotrauma, 14: 885-95 (1997)  1997

      Show Abstract
      9475370 9475370
      Cloning and characterization of a metabotropic glutamate receptor, mGluR4b.
      Thomsen, C, et al.
      Neuropharmacology, 36: 21-30 (1997)  1997

      Show Abstract
      9144638 9144638