05-446 | Anti-p75NTR (Neurotrophin Receptor) Antibody, clone ME20.4

05-446
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MkIP, WB, IHC, NEUTMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-446
      Replaces04-1111
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-p75NTR (Neurotrophin Receptor) Antibody, clone ME20.4
      Alternate Names
      • p75 Low Affinity Neurotrophin Receptor
      • NGFR
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      Applications
      ApplicationAnti-p75NTR (Neurotrophin Receptor) Antibody, clone ME20.4 detects level of p75NTR (Neurotrophin Receptor) & has been published & validated for use in IP, WB, IH, NEUT.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      • Immunohistochemistry
      • Neutralizing
      Biological Information
      ImmunogenHuman melanoma cell line WM245.
      CloneA16/17
      HostMouse
      Specificitylow affinity p75NTR
      IsotypeIgG1
      Species Reactivity
      • Human
      • Monkey
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryNerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain.
      Gene Symbol
      • NGFR
      • Gp80-LNGFR
      • CD271
      • p75(NTR)
      • TNFRSF16
      Purification MethodProtein G Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08138 # Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
      SIZE: 427 amino acids; 45183 Da
      SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      DOMAIN: SwissProt: P08138 Death domain is responsible for interaction with RANBP9.
      PTM: N- and O-glycosylated. & O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. & Phosphorylated on serine residues.
      SIMILARITY: Contains 1 death domain. & Contains 4 TNFR-Cys repeats.
      Molecular Weight69kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from HS294T cells
      Sales RestrictionsDue to license agreement restrictions, this product cannot be purchased for resale.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-p75NTR (Neurotrophin Receptor), clone ME20.4 2484171
      Anti-p75NTR (Neurotrophin Receptor), clone ME20.4 (mouse monoclonal IgG1) - 2453196 2453196
      Anti-p75NTR (Neurotrophin Receptor), clone ME20.4 (mouse monoclonal IgG1) 2941483
      Anti-p75NTR (Neurotrophin Receptor), clone ME20.4 (mouse monoclonal IgG1) 2982396
      Anti-p75NTR (Neurotrophin Receptor), clone ME20.4 (mouse monoclonal IgG1) 2786054
      Anti-p75NTR (Neurotrophin Receptor), clone ME20.4 (mouse monoclonal IgG1) 2880679
      Anti-p75NTR (Neurotrophin Receptor), clone ME20.4 - 16395 16395
      Anti-p75NTR (Neurotrophin Receptor), clone ME20.4 - 22972 22972
      Anti-p75NTR (Neurotrophin Receptor), clone ME20.4 - 27808 27808
      Anti-p75NTR (Neurotrophin Receptor), clone ME20.4 - DAM1831386 DAM1831386

      References

      Reference overviewApplicationPub Med ID
      Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
      Huang, SX; Islam, MN; O'Neill, J; Hu, Z; Yang, YG; Chen, YW; Mumau, M; Green, MD; Vunjak-Novakovic, G; Bhattacharya, J; Snoeck, HW
      Nature biotechnology  32  84-91  2014

      Show Abstract
      24291815 24291815
      The p75 neurotrophin receptor is expressed by adult mouse dentate progenitor cells and regulates neuronal and non-neuronal cell genesis.
      Bernabeu, RO; Longo, FM
      BMC neuroscience  11  136  2010

      Show Abstract Full Text Article
      20961458 20961458
      Preconditioning selective ventral root injury promotes plasticity of ascending sensory neurons in the injured spinal cord of adult rats--possible roles of brain-derived neurotrophic factor, TrkB and p75 neurotrophin receptor.
      Fang Li,Li Li,Xing-Yun Song,Jin-Hua Zhong,Xue-Gang Luo,Cory J Xian,Xin-Fu Zhou
      The European journal of neuroscience  30  2009

      Show Abstract
      19788572 19788572
      Basal cells as stem cells of the mouse trachea and human airway epithelium.
      Rock, JR; Onaitis, MW; Rawlins, EL; Lu, Y; Clark, CP; Xue, Y; Randell, SH; Hogan, BL
      Proceedings of the National Academy of Sciences of the United States of America  106  12771-5  2009

      Show Abstract
      19625615 19625615
      Activity- and Ca(2+)-dependent modulation of surface expression of brain-derived neurotrophic factor receptors in hippocampal neurons
      Du, J., et al
      J Cell Biol, 150:1423-34 (2000)  2000

      Immunoblotting (Western)10995446 10995446
      Immunohistochemical detection of p140trkA and p75LNGFR neurotrophin receptors in neuroblastoma.
      Dominici, C, et al.
      J. Neurooncol., 31: 57-64 (1997)  1997

      Show Abstract
      9049831 9049831
      Immuno-electron microscopy characterization of human bone marrow stromal cells with anti-NGFR antibodies.
      Caneva, L, et al.
      Blood Cells Mol. Dis., 21: 73-85 (1995)  1995

      Show Abstract
      8846047 8846047
      Low-affinity nerve growth factor receptor immunoreactivity in the human urinary bladder.
      Wakabayashi, Y, et al.
      Neurosci. Lett., 186: 9-12 (1995)  1995

      Show Abstract
      7783954 7783954
      Characterization of nerve growth factor receptor in neural crest tumors using monoclonal antibodies
      Ross, A H, et al
      Proc Natl Acad Sci USA, 81:6681-5 (1984)  1984

      6093111 6093111

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      Life Science Research > Antibodies and Assays > Primary Antibodies