05-673 | Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody, clone BK102

200 µg  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, RWBMPurifiedMonoclonal Antibody
      Catalogue Number05-673
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody, clone BK102
      Product Information
      • Acid extracts of HeLa cells
      PresentationProtein A Purified immunoglobulin in 0.1M Tris-Glycine, 0.15M NaCl and 0.05% sodium azide, pH 7.4.
      ApplicationDetect phospho-Acetyl CoA Carboxylase (Ser79) using this Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody, clone BK102 validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenSynthetic peptide corresponding to rat Acetyl CoA Carboxylase
      SpecificityRecognizes phosphorylated Acetyl CoA Carboxylase (Ser79).
      Species Reactivity
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryAcetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
      Gene Symbol
      • ACACA
      • ACC-alpha
      • ACCA
      • ACC
      • ACC1
      • ACAC
      • Phosphorylation
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q13085 # Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
      COFACTOR: Biotin. & Binds 2 manganese ions per subunit.
      SIZE: 2346 amino acids; 265554 Da
      SUBUNIT: Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis.
      TISSUE SPECIFICITY: Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
      PTM: Phosphorylation on Ser-1263 is required for interaction with BRCA1.
      SIMILARITY: SwissProt: Q13085 ## Contains 1 ATP-grasp domain. & Contains 1 biotin carboxylation domain. & Contains 1 biotinyl-binding domain. & Contains 1 carboxyltransferase domain.
      Molecular Weight257 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot on HeLa acid extracts
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-p54nrb/NonO, clone 78-1-C6 -2530019 2530019
      Anti-phospho-Acetyl CoA Carboxylase (Ser79), clone BK102 - 1993391 1993391
      Anti-phospho-Acetyl CoA Carboxylase (Ser79), clone BK102 - 22326 22326
      Anti-phospho-Acetyl CoA Carboxylase (Ser79), clone BK102 - 27329 27329
      Anti-phospho-Acetyl CoA Carboxylase (Ser79), clone BK102 - 32516 32516
      Anti-phospho-Acetyl CoA Carboxylase (Ser79), clone BK102 - DAM1636074 DAM1636074
      Anti-phospho-Acetyl CoA Carboxylase (Ser79), clone BK102 - DAM1690641 DAM1690641
      Anti-phospho-Acetyl CoA Carboxylase (Ser79), clone BK102 - JBC1382343 JBC1382343
      Anti-phospho-Acetyl CoA Carboxylase (Ser79), clone BK102 - JBC1938963 JBC1938963
      Anti-phospho-Acetyl CoA Carboxylase (Ser79), clone BK102 - NG1630179 NG1630179


      Reference overviewPub Med ID
      Combinatorial interactions are required for the efficient recruitment of pho repressive complex (PhoRC) to polycomb response elements.
      Kahn, TG; Stenberg, P; Pirrotta, V; Schwartz, YB
      PLoS genetics  10  e1004495  2014

      Show Abstract
      25010632 25010632
      Regulation of skeletal muscle oxidative capacity and muscle mass by SIRT3.
      Lin, L; Chen, K; Abdel Khalek, W; Ward, JL; Yang, H; Chabi, B; Wrutniak-Cabello, C; Tong, Q
      PloS one  9  e85636  2014

      Show Abstract
      24454908 24454908
      Effect of exercise intensity on skeletal muscle AMPK signaling in humans.
      Zhi-Ping Chen, Terry J Stephens, Sid Murthy, Benedict J Canny, Mark Hargreaves, Lee A Witters, Bruce E Kemp, Glenn K McConell
      Diabetes  52  2205-12  2003

      Show Abstract
      12941758 12941758
      AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation.
      Chen, Z P, et al.
      Am. J. Physiol. Endocrinol. Metab., 279: E1202-6 (2000)  2000

      Show Abstract
      11052978 11052978
      Dealing with energy demand: the AMP-activated protein kinase.
      Kemp, B E, et al.
      Trends Biochem. Sci., 24: 22-5 (1999)  1999

      Show Abstract
      10087918 10087918