05-900 | Anti-phospho-Met (Tyr1234/1235) Antibody, clone NL8, rabbit monoclonal

100 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbPurifiedMonoclonal Antibody
      Catalogue Number05-900
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-Met (Tyr1234/1235) Antibody, clone NL8, rabbit monoclonal
      Alternate Names
      • c-Met
      • cmet
      • HGFR
      • RCCP2
      • met proto-oncogene (hepatocyte growth factor receptor)
      Product Information
      ApplicationAnti-phospho-Met (Tyr1234/1235) Antibody, clone NL8 detects level of phospho-Met (Tyr1234/1235) & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated, synthetic peptide (...KE[pY][pY}SV...) in which pYpY corresponds to phosphorylated amino acids 1234 and 1235 of human Met/HGFR
      Specificityphosphorylated Met, cross-reacts with phosphorylated EGFR
      Species Reactivity
      • Human
      Species Reactivity NoteBroad species cross-reactivity expected due to sequence homology
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma.
      Gene Symbol
      • MET
      • HGFR
      • AUTS9
      • c-Met
      • RCCP2
      • Phosphorylation
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08581 # Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity.
      SIZE: 1390 amino acids; 155527 Da
      SUBUNIT: Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      DISEASE: SwissProt: P08581 # Activation of MET after rearrangement with the TPR gene produces an oncogenic protein. & Defects in MET may be associated with gastric cancer. & Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550]. & Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074]; also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance. & Genetic variations in MET may be associated with susceptibility to autism type 1B (AUTS1B) [MIM:608636]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior.
      SIMILARITY: SwissProt: P08581 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. & Contains 3 IPT/TIG domains. & Contains 1 protein kinase domain. & Contains 1 Sema domain.
      Molecular WeightMr 140kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from NIH-3T3 cells co-expressing Met/HGFR and HGF
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditionsstable 2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information


      Certificates of Analysis

      TitleLot Number
      Anti-phospho-Met (Tyr1234/1235), clone NL8 - 30368 30368


      Reference overviewPub Med ID
      Has HGF met other partners? Met-independent epithelial morphogenesis induced by HGF. focus on "Hepatocyte growth factor induces MDCK cell morphogenesis without causing loss of tight junction functional integrity".
      Devarajan, Prasad
      Am. J. Physiol., Cell Physiol., 286: C475-7 (2004)  2004

      14761880 14761880
      Therapeutic targeting of the receptor tyrosine kinase Met.
      Sattler, Martin, et al.
      Cancer Treat. Res., 119: 121-38 (2004)  2004

      15164876 15164876
      Prostate cancer and the met hepatocyte growth factor receptor.
      Knudsen, Beatrice S and Edlund, Magnus
      Adv. Cancer Res., 91: 31-67 (2004)  2004

      Show Abstract
      15327888 15327888
      c-Met: structure, functions and potential for therapeutic inhibition.
      Ma, Patrick C, et al.
      Cancer Metastasis Rev., 22: 309-25 (2003)  2003

      Show Abstract
      12884908 12884908
      Met, metastasis, motility and more.
      Birchmeier, Carmen, et al.
      Nat. Rev. Mol. Cell Biol., 4: 915-25 (2003)  2003

      14685170 14685170

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      Life Science Research > Antibodies and Assays > Primary Antibodies