07-790 | Anti-phospho-PKCα (Ser657/Tyr658) Antibody

07-790
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, RbELISA, IP, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-790
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-PKCα (Ser657/Tyr658) Antibody
      Alternate Names
      • PRKCA
      • PKC-alpha
      • PKCA
      • PRKACA
      References
      Product Information
      FormatAffinity Purified
      Applications
      ApplicationAnti-phospho-PKCα (Ser657/Tyr658) Antibody detects level of phospho-PKCα (Ser657/Tyr658) & has been published & validated for use in ELISA, IP & WB.
      Key Applications
      • ELISA
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenKLH conjugated peptide corresponding to amino acid region encompassing the human phospho-PKCα (Ser657/Tyr658).
      HostRabbit
      SpecificityRecognizes phospho-PKCα (Ser657/Tyr658). This sequence is similar to PKCβI (Ser661/Tyr662) and PKCγ (Thr674/Tyr675).
      IsotypeIgG
      Species Reactivity
      • Human
      • Rat
      • Rabbit
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryProtein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
      Gene Symbol
      • PRKCA
      • PKC-A
      • PKCA
      • MGC129901
      • AAG6
      • MGC129900
      • PRKACA
      • PKC-alpha
      Modifications
      • Phosphorylation
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P17252 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
      COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).
      SIZE: 672 amino acids; 76764 Da
      SUBUNIT: Interacts with CENTA1, CSPG4 and PRKCABP. Binds to SDPR in the presence of phosphatidylserine.
      SIMILARITY: SwissProt: P17252 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.
      Molecular Weight82 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-phospho-PKCa (Ser657/Tyr658) (Affinity purified Rabbit polyclonal IgG) - 2088973 2088973
      Anti-phospho-PKCa (Ser657/Tyr658) (Affinity purified Rabbit polyclonal IgG) - 2205927 2205927
      Anti-phospho-PKCa (Ser657/Tyr658) (Affinity purified rabbit polyclonal IgG) 2911576
      Anti-phospho-PKCa (Ser657/Tyr658) - 2058352 2058352
      Anti-phospho-PKCa (Ser657/Tyr658) - 2289158 2289158
      Anti-phospho-PKCa (Ser657/Tyr658) - NG1865615 NG1865615
      Anti-phospho-PKCa (Ser657/Tyr658) - NG1897061 NG1897061
      Anti-phospho-PKCalpha; (Ser657/Tyr658) - 0603026243 0603026243
      Anti-phospho-PKCα (Ser657/Tyr658) (Affinity purified Rabbit polyclonal IgG) 2480721
      Anti-phospho-PKCα (Ser657/Tyr658) (Affinity purified Rabbit polyclonal IgG) 2879111

      References

      Reference overviewApplicationPub Med ID
      Spatial distribution of epigenetic modifications in Brachypodium distachyon embryos during seed maturation and germination.
      Wolny, E; Braszewska-Zalewska, A; Hasterok, R
      PloS one  9  e101246  2014

      Show Abstract
      25006668 25006668
      Tissue-specific epigenetic modifications in root apical meristem cells of Hordeum vulgare.
      Braszewska-Zalewska, AJ; Wolny, EA; Smialek, L; Hasterok, R
      PloS one  8  e69204  2013

      Show Abstract
      Immunofluorescence23935955 23935955
      Phosphorylated HSP27 modulates the association of phosphorylated caldesmon with tropomyosin in colonic smooth muscle
      Somara, Sita and Bitar, Khalil N
      Am J Physiol Gastrointest Liver Physiol, 291:G630-9 (2006)  2006

      16627824 16627824

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies