05-1143 Anti-phospho-Paxillin (Tyr31) Antibody, clone M102

100 µL  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
Request Pricing
Limited AvailabilityLimited Availability
In Stock 
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Special Offers


      Contact Customer Service

      Click To Print This Page


      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Catalogue Number05-1143
      DescriptionAnti-phospho-Paxillin (Tyr31) Antibody, clone M102
      Background InformationPaxillin is involved in focal adhesion formation during cell adhesion and migration. Paxillin contains LD motifs, LIM domains, and an SH3- and SH2-binding domain that participate in a variety of protein-protein interactions with kinases, GTPase-activating proteins, and cytoskeletal proteins. Phosphorylation of paxillin occurs at both tyrosine and serine sites. Tyrosine phosphorylation of paxillin occurs in response to growth factors, neuropeptides, and integrins. The major sites of tyrosine phosphorylation include Tyr31 and Tyr118. Both of these sites may be involved in Crk binding to paxillin during integrin-mediated cell adhesion. These sites may provide docking motifs for recruitment of other signaling molecules to focal adhesions.
      Product Information
      • Pervanadate treated L6 cell lysates
      PresentationPurified monoclonal IgG1 in phosphate-buffered saline, 50% glycerol, 1 mg/mL BSA, and 0.05% sodium azide.
      ApplicationDetect phospho-Paxillin (Tyr31) using this Anti-phospho-Paxillin (Tyr31) Antibody, clone M102 validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenClone M102 was generated from phospho-Paxillin (Tyr31) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 31 of human paxillin. This human sequence is highly conserved in rat and mouse paxillin.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThe antibody detects Paxillin phosphorylated at Tyr31.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FLJ16691
      • paxillin
      • Phosphorylation
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
      SUBUNIT STRUCTURE: Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1 By similarity. Binds ASAP2. Interacts with unphosphorylated ITGA4. Interacts with RNF5.
      SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton. Cell junction › focal adhesion.
      PTM: Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens.
      SEQUENCE SIMILARITIES: Belongs to the paxillin family.
      Contains 4 LIM zinc-binding domains.
      Molecular Weight72 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by western Blot in pervanadate treated L6 cell lysates.
      Western Blot Analysis: 1:500 dilution of this lot detected phospho-Paxillin on 10 µg of pervanadate treated L6 lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C for one year from date of receipt. Do not aliquot.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-phospho-Paxillin (Tyr31), -25184702518470
      Anti-phospho-Paxillin (Tyr31), -27791332779133
      Anti-phospho-Paxillin (Tyr31), clone M102 - 22049442204944
      Anti-phospho-Paxillin (Tyr31), clone M102 - NG1727629NG1727629
      Anti-phospho-Paxillin (Tyr31), clone M102 - NG1842848NG1842848
      Anti-phospho-Paxillin (Tyr31), clone M102 - NG1915716NG1915716
      Anti-phospho-Paxillin (Tyr31), clone M102 - NRG1701185NRG1701185
      Anti-phospho-Paxillin (Tyr31), clone M102 Monoclonal Antibody3068665
      Anti-phospho-Paxillin (Tyr31), clone M102 Monoclonal Antibody3131889

      Related Products & Applications

      Related Products

      Catalogue Number Description  
      05-417 Anti-Paxillin Antibody, clone 5H11 Show Pricing & Availability
      07-1441 Anti-phospho-Paxillin (Ser126) Antibody Show Pricing & Availability
      07-733 Anti-phospho-Paxillin (Tyr118) Antibody Show Pricing & Availability
      AB1962 Anti-Paxillin Antibody, phospho-specific [Ser178] Show Pricing & Availability
      AB3794 Anti-Paxillin Antibody Show Pricing & Availability
      MAB3060 Anti-Paxillin Antibody, clone 349 Show Pricing & Availability


      Life Science Research > Antibodies and Assays > Primary Antibodies