07-909 | Anti-phospho-Src (Tyr418) Antibody

07-909
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Ch, H, MICC, IHC, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-909
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-Src (Tyr418) Antibody
      Alternate Names
      • c-Src
      • p60-Src Src kinase
      References
      Product Information
      FormatAffinity Purified
      Control
      • Chick embryo fibroblast (CEF) cells expressing human wild-type Src protein
      PresentationAffinity Purified rabbit polyclonal IgG in PBS (without Mg2+ and Ca2+), pH 7.3 containing 0.5 mg/mL BSA (IgG, protease free) and 0.025% sodium azide and 50% glycerol.
      Applications
      ApplicationAnti-phospho-Src (Tyr418) Antibody detects level of phospho-Src (Tyr418) & has been published & validated for use in IC, IH & WB.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      • Western Blotting
      Application NotesImmunoblot Analysis: 1:1000 dilutions of this lot detected phospho-Src (Tyr418) in RIPA lysate of Src transfected CEF cells.
      Biological Information
      ImmunogenPeptide corresponding to amino acid region encompassing the human, mouse, rat, chicken, and frog phospho-Src (Tyr418)
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes Src phosphorylated on Tyrosine residue 418.
      IsotypeIgG
      Species Reactivity
      • Chicken
      • Human
      • Mouse
      Species Reactivity NotePredicted to cross-react with Rat and Frog (100% homologous) based on sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
      Gene Symbol
      • SRC
      • ASV
      • c-src
      • p60-Src
      • SRC1
      • c-SRC
      • pp60c-src
      Modifications
      • Phosphorylation
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummarySIZE: 536 amino acids; 59835 Da
      SUBUNIT: Interacts with DDEF1/ASAP1 via its SH3 domain. Interacts with CCPG1 (By similarity). Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2.
      PTM: Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity.
      SIMILARITY: SwissProt: P12931 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
      Molecular Weight60 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-phospho-Src (Tyr418) (Affinity purified Rabbit polyclonal IgG) - 2397041 2397041
      Anti-phospho-Src (Tyr418) (Affinity purified Rabbit polyclonal IgG) - 2428517 2428517
      Anti-phospho-Src (Tyr418) (Affinity purified Rabbit polyclonal IgG) 2953960
      Anti-phospho-Src (Tyr418) (Affinity purified Rabbit polyclonal IgG) - 2193288 2193288
      Anti-phospho-Src (Tyr418) (Affinity purified Rabbit polyclonal IgG) - 2224380 2224380
      Anti-phospho-Src (Tyr418) (Affinity purified Rabbit polyclonal IgG) - DAM1460232 DAM1460232
      Anti-phospho-Src (Tyr418) (Affinity purified Rabbit polyclonal IgG) -2502904 2502904
      Anti-phospho-Src (Tyr418) - 2026363 2026363
      Anti-phospho-Src (Tyr418) - 2887959 2887959
      Anti-phospho-Src (Tyr418) - 2929263 2929263

      References

      Reference overviewPub Med ID
      Functional stability of a mixed microbial consortium producing PHA from waste carbon sources.
      Erik R Coats,Frank J Loge,William A Smith,David N Thompson,Michael P Wolcott
      Applied biochemistry and biotechnology  137-140  2007

      Show Abstract
      18478444 18478444
      Src: regulation, role in human carcinogenesis and pharmacological inhibitors.
      Tsygankov, A Y and Shore, S K
      Curr. Pharm. Des., 10: 1745-56 (2004)  2004

      Show Abstract
      15180537 15180537
      c-Src and cooperating partners in human cancer
      Ishizawar, Rumey and Parsons, Sarah J
      Cancer Cell, 6:209-14 (2004)  2004

      15380511 15380511
      Src protein-tyrosine kinase structure and regulation.
      Roskoski, Robert
      Biochem. Biophys. Res. Commun., 324: 1155-64 (2004)  2004

      Show Abstract
      15504335 15504335

      Data Sheet

      Title
      Anti-phospho-Src (Tyr418)

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies