FC014 | Fibronectin, Bovine

FC014
500 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Key Applications
      CULT
      Description
      Catalogue NumberFC014
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionFibronectin, Bovine
      OverviewBovine fibronectin was purified from bovine plasma over a gelatin agarose column. A single band at 220kDa (reduced) is identified, corresponding to intact fibronectin under reduced conditions.
      References
      Product Information
      PresentationLiquid in a solution of 2M Urea in 0.05 M Tris pH 7.0.
      Applications
      Key Applications
      • Cell Culture
      Application NotesELISA, Ouchterlony and immunoblotting.
      Biological Information
      Concentration1.0 mg/mL
      PurityAffinity purified to approximately 95%, as determined by SDS-PAGE.
      SourceBovine plasma
      Entrez Gene SummaryThis gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined.
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P02751 # Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth (By similarity).
      SIZE: 2386 amino acids; 262607 Da
      SUBUNIT: Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1.
      SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
      TISSUE SPECIFICITY: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.DEVELOPMENTAL STAGE: Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age.
      PTM: Sulfated.
      SIMILARITY: SwissProt: P02751 ## Contains 12 fibronectin type-I domains. & Contains 2 fibronectin type-II domains. & Contains 16 fibronectin type-III domains.
      Stem Cell Type
      • Mouse Embryonic Stem Cells
      • Mesenchymal Stem Cells
      • Neural Stem Cells
      • Hematopoietic Stem Cells
      • Epithelial Cells
      • Pancreatic Stem Cells
      • Induced Pluripotent Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsAliquot and store up to 12 months at -20°C. For short term (1-2 weeks) use, storage at 2-8°C is acceptable. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size500 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      BOVINE FIBRONECTIN 2474922
      BOVINE FIBRONECTIN - 2060959 2060959
      BOVINE FIBRONECTIN - 2301407 2301407
      BOVINE FIBRONECTIN - 2851773 2851773
      BOVINE FIBRONECTIN -2685543 2685543
      BOVINE FIBRONECTIN -2740944 2740944
      BOVINE FIBRONECTIN -2764902 2764902
      BOVINE FIBRONECTIN -2775452 2775452

      References

      Reference overviewPub Med ID
      Comparative studies on amniotic fluid and plasma fibronectins
      Ruoslahti E. et al.
      Biochem. J, 193:295-299 (1981)  1981

      7305927 7305927

      Data Sheet

      Title
      Fibronectin, Bovine - Data Sheet

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      Categories

      Life Science Research > Proteins and Enzymes > ECM Proteins for Plate Coating