12-533 | GSM (GSK3 substrate peptide)

12-533
1 mg  
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      Overview

      Replacement Information
      Description
      Catalogue Number12-533
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionGSM (GSK3 substrate peptide)
      OverviewSynthetic peptide (RRRPASVPPSPSLS RHS(pS)HQRR) based on muscle glycogen synthase 1, where (pS) corresponds to phosphorylated serine.
      References
      Product Information
      Presentation1 mg of GSM lyophilized from 1 mL sterile, distilled water. Lyophilized powder.
      Applications
      Key Applications
      • Kinase Assay
      Application NotesKinase Assay: Substrate for GSK3α, active (Catalog # 14-492), GSK3β, active (Catalog # 14-306), GSK3β, active, rat (Catalog # 14-538).
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryGlycogen synthase kinase 3-alpha (GSK3A; EC {2.7.1.37}) is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase (see GYS1, {138570}) and transcription factors (e.g., JUN, {165160}). It also plays a role in the WNT ({164820}) and PI3K (see PIK3CG, {601232}) signaling pathways (see review by {1:Ali et al. (2001)}).[supplied by OMIM]
      Gene Symbol
      • GSK3A
      • DKFZp686D0638
      Protein TargetGSK3
      Target Sub-FamilyCMGC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P49840 # Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN (By similarity).
      SIZE: 483 amino acids; 50981 Da
      SUBUNIT: Monomer (By similarity).
      SIMILARITY: SwissProt: P49840 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. & Contains 1 protein kinase domain.
      Molecular WeightMolecular weight: 2673 Daltons.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated as a substrate for GSK3β (Catalog # 14-306).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsLyophilized: 2 years at -20°C. Rehydrated: 6 months at -20°C
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      GSM (GSK3 substrate peptide) 2915295
      GSM (GSK3 substrate peptide) 2470375
      GSM (GSK3 substrate peptide) 3002642
      GSM (GSK3 substrate peptide) -
      GSM (GSK3 substrate peptide) - 0611045252 0611045252
      GSM (GSK3 substrate peptide) - 1350556 1350556
      GSM (GSK3 substrate peptide) - 1947720 1947720
      GSM (GSK3 substrate peptide) - 1992473 1992473
      GSM (GSK3 substrate peptide) - 2167132 2167132
      GSM (GSK3 substrate peptide) - 2281617 2281617

      References

      Reference overviewApplicationPub Med ID
      Glycogen synthase kinase-3 inhibition by lithium and beryllium suggests the presence of two magnesium binding sites
      Ryves, W. J., et al
      Biochem Biophys Res Commun, 290:967-72 (2002)  2002

      Kinase Assay11798168 11798168
      An assay for glycogen synthase kinase 3 (GSK-3) for use in crude cell extracts
      Ryves, W. J., et al
      Anal Biochem, 264:124-7 (1998)  1998

      Kinase Assay9784196 9784196

      Related Products & Applications

      Product Families

      Categories

      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Kinase & Phosphatase Substrates
      Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Kinase & Phosphatase Substrates