ECM435 | Integrin Classics Kit

ECM435
1 kit  
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      Overview

      Replacement Information
      Description
      Catalogue NumberECM435
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionIntegrin Classics Kit
      OverviewChemicon Investigator Kits for Integrin Research are a cost-effective source of reagents for all investigators intimately involved with this expanding field of study. The Integrin Classics Investigator Kit contains several of Chemicon's most popular integrin antibodies, and allows an initial screenings with small quantities of these antibodies. All antibodies in the Integrin Classics kit are available for purchase individually in larger sizes.

      Integrins belong to a large family of cell surface proteins commonly referred to as glycoproteins. Integrins are composed of noncovalently associated alpha and beta subunits which make up heterodimers: the larger termed alpha chain and the smaller beta chain. At least 16 alpha subunits and 8 beta subunits are expressed, which can give rise to 22 different integrins. Integrins are thought to play critical roles in cell migration, differentiation, and survival. There is now considerable evidence that these transmembrane receptors play an important role in the regulation of gene expression and signal transduction. Excellent reviews of integrin structure, function, and ligand specificity may be found in: Hynes, R. 1992. Cell 69:11-25; Kramer, R. 1993. "Integrin Structure and Ligand Specificity in Cell-Matrix Interactions" in Molecular and Cellular Aspects of Basement Membranes. Academic Press.

      Chemicon offers the Integrin Classics Investigator Kit for initial screenings for several well-studied integrins. The reagents in this kit are not application specific but rather may be used in a variety of procedures, depending upon the needs of the individual investigator.
      References
      Product Information
      Components
      • alphaV Mouse Monoclonal Antibody (Part No. MAB1953Z-20) - 1 tube, 20 μg.
      • beta1 Mouse Monoclonal Antibody (Part No. MAB1951Z-20)- 1 tube, 20 μg.
      • beta2 Mouse Monoclonal Antibody (Part No. MAB1962Z-20) - 1 tube, 20 μg.
      • alpha5beta1 Mouse Monoclonal Antibody (Part No. MAB1999-20) - 1 tube, 20 μg.
      • alphaVbeta3 Mouse Monoclonal Antibody (Part No. MAB 1976Z-20) -1 tube, 20 μg.
      • alphaVbeta5 Mouse Monoclonal Antibody (Part No. MAB1961Z-20)- 1 tube, 20 μg.
      PresentationThis kit contains some of Chemicon's most popular monoclonals to alphaV, beta1, beta2, alphaVbeta3, alpha5beta1, and alphaVbeta5. 20μg each.
      Applications
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      • Enzyme Assays
      • Immunohistochemistry
      Biological Information
      Species Reactivity
      • Human
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore antibodies at -20°C.

      Important Note: Due to the small volumes contained within the kit, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid entrapped in the container's cap during shipment.
      Packaging Information
      Material Size1 kit
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      References

      Reference overviewPub Med ID
      Association of Ang-2 with integrin beta 2 controls Ang-2/PDGF-BB-dependent upregulation of human peripheral blood monocyte fibrinolysis.
      Louise Bezuidenhout,Peter Zilla,Neil Davies
      Inflammation  32  2009

      Show Abstract
      19728062 19728062
      TGFbeta-induced protein mediates lymphatic endothelial cell adhesion to the extracellular matrix under low oxygen conditions.
      M Irigoyen,E Ansó,E Salvo,J Dotor de las Herrerías,J J Martínez-Irujo,A Rouzaut
      Cellular and molecular life sciences : CMLS  65  2008

      Show Abstract
      18560760 18560760

      Data Sheet

      Title
      Integrin Classics Kit - Data Sheet
      Integrin Classics Kit - Data Sheet