ECM420 | Laminin-Specific Integrins Investigator Kit

ECM420
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      Overview

      Replacement Information
      Description
      Catalogue NumberECM420
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionLaminin-Specific Integrins Investigator Kit
      OverviewChemicon Investigator Kits for Integrin Research are a cost-effective source of reagents for all investigators intimately involved with this expanding field of study. The kit is designed for research focusing on integrins which are known to interact with Laminin. These include alpha1, alpha2, alpha3, alpha6, and alpha7 (not included with kit) which combine with the integrin beta1 subunit. The alpha6 subunit is also known to combine with the beta4 subunit. [Hynes, R. 1992. Cell 69:11-25]

      Integrins belong to a large family of cell surface proteins commonly referred to as glycoproteins. Integrins are composed of noncovalently associated alpha and beta subunits which make up heterodimers: the larger termed alpha chain and the smaller beta chain. At least 16 alpha subunits and 8 beta subunits are expressed, which can give rise to 22 different integrins. Integrins are thought to play critical roles in cell migration, differentiation, and survival. There is now considerable evidence that these transmembrane receptors play an important role in the regulation of gene expression and signal transduction. Excellent reviews of integrin structure, function, and ligand specificity may be found in: Hynes, R. 1992. Cell 69:11-25; Kramer, R. 1993. "Integrin Structure and Ligand Specificity in Cell-Matrix Interactions" in Molecular and Cellular Aspects of Basement Membranes. Academic Press.

      Chemicon offers the Laminin-Specific Integrins Investigator Kit for initial studies of Integrin/Laminin interactions. All kit reagents are also available in larger sizes. The reagents in this kit are not application specific but rather may be used in a variety of procedures, depending upon the needs of the individual investigator.
      References
      Product Information
      Components
      • alpha1 Mouse Monoclonal Antibody (Part No. MAB1973Z-20) - 1 tube, 20 μg.
      • alpha2 Mouse Monoclonal Antibody (Part No. MAB1950Z-20)- 1 tube, 20 μg.
      • alpha3 Mouse Monoclonal Antibody (Part No. MAB2056-20) - 1 tube, 20 μg.
      • alpha6 Rat Monoclonal Antibody (Part No. MAB1378-20)- 1 tube, 20 μg.
      • beta1 Mouse Monoclonal Antibody (Part No. MAB1951Z-20) - 1 tube, 20 μg.
      • beta4 Mouse Monoclonal Antibody (Part No. MAB2058-20) - 1 tube, 20 μg.
      PresentationChemicon's Laminin Specific Integrins Kit (ECM420) is useful for the study of Laminin-associated integrins. Chemicon's ECM420 kit provides 20 μg each of monoclonals to alpha1, alpha2, alpha3, alpha6, beta1, and beta4.
      Applications
      Key Applications
      • ELISA
      Biological Information
      Species Reactivity
      • Human
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore antibodies at -20°C.

      Important Note: Due to the small volumes contained within the kit, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge before opening to dislodge any liquid entrapped in the container's cap during shipment.
      Packaging Information
      Material Size1 kit
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      References

      Reference overviewPub Med ID
      Integrin α6(high) cell population functions as an initiator in tumorigenesis and relapse of human liposarcoma.
      Lu Wang,Lingxian Wang,Yanhong Gu,Yongqian Shu,Yan Shen,Qiang Xu
      Molecular cancer therapeutics  10  2011

      Show Abstract
      21980129 21980129

      Data Sheet

      Title
      Laminin-Specific Integrins Investigator Kit - Data Sheet
      Laminin-Specific Integrins Investigator Kit - Data Sheet