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MAB2641 Anti-Fibrillin (Pan) Antibody, clone 689

Anti-Fibrillin (Pan) Antibody, clone 689 detects level of Fibrillin (Pan) & has been published & validated for use in IH, ELISA.

Anti-Fibrillin (Pan) Antibody, clone 689 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: ECM Proteins Gene Symbol: EFEMP1, FBNL, MLVT, FBLN3, RAD, fibrillin-like, Fibulin-3, S1-5, FIBL-3, HRD, MTLV UniProt Number: Q75N90
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MAB2641
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, H, ChIHC, ELISAMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB2641
      DescriptionAnti-Fibrillin (Pan) Antibody, clone 689
      Alternate Names
      • EGF-containing fibulin-like extracellular matrix protein 1
      • Fibrillin-like protein
      • Extracellular protein S1-5
      Background InformationFibrillins are glycosolated and disulfide-rich components of the extracellular matrix belonging to the Fibrillin-LTBP protein family. They serve an important function in both nonelastic and elastic tissues such as eye, bone and blood vessels. The functional units of Fibrillin are known as microfibrils, multiprotein assemblies, which act as structural scaffolding for the limiting of the tissue elasticity, structural integrity of different organ systems, the assembly of elastic fibers, and regulation of BMP growth factor signaling. There are three known isoforms; Fibrillin 1, Fibrillin 2, and Fibrillin 3. Fibrillin 3 is the most recently described member of the Fibrillin family, with highest expression in the brain. Alterations in the microfibril assembly often occur in patients with fibrillinopathies such as; Congenital Contractual Arachnodactyly (CCA) which results in disruption of Fibrillin 2, and Marfan’s syndrome resulting from Fibrillin 1 mutation.
      References
      Product Information
      FormatPurified
      Control
      • Mouse skin tissue
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Fibrillin (Pan) Antibody, clone 689 detects level of Fibrillin (Pan) & has been published & validated for use in IH, ELISA.
      Key Applications
      • Immunohistochemistry
      • ELISA
      Application NotesELISA Analysis: This antibody has been used by an independent laboratory in ELISA (Corson, 2003).
      Biological Information
      ImmunogenRecombinant protein corresponding to human Fibrillin 3.
      Clone689
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThe antibody recognizes isoforms 1, 2, and 3 of fibrillin.
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      • Human
      • Chicken
      Species Reactivity NoteDemonstrated to react with mouse. Predicted to react with human and chicken based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a protein that belongs to the fibrillin gene family. Fibrillins are extracellular matrix molecules that assemble into microfibrils in many connective tissues. This gene is most highly expressed in fetal tissues and its protein product is localized to extracellular microfibrils of developing skeletal elements, skin, lung, kidney, and skeletal muscle. This gene is potentially involved in Weill-Marchesani syndrome. While several transcript variants may exist for this gene, their full-length natures have not been described to date. [provided by RefSeq].
      Gene Symbol
      • EFEMP1
      • FBNL
      • MLVT
      • FBLN3
      • RAD
      • fibrillin-like
      • Fibulin-3
      • S1-5
      • FIBL-3
      • HRD
      • MTLV
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-containing microfibrils provide long-term force bearing structural support.

      SUBCELLULAR LOCATION: Secreted › extracellular space › extracellular matrix

      TISSUE SPECIFICITY: Predominantly expressed in connective tissues such as skeletal muscle, tendon, skin, perichondrium and periosteum. Highly expressed in fetal lung, brain, kidney. Expressed at low level in prostate, testis, mammary gland, uterus, ovary, placenta, bladder, adrenal gland, thyroid, fetal thymus, fetal liver, liver, fetal heart and heart.

      PTM: Probably forms intermolecular disulfide bonds either with other FBN3 molecules or with other components of the microfibrils (by similarity).

      SEQUENCE SIMILARITIES: Belongs to the fibrillin family.

      Contains 44 EGF-like domains.

      Contains 9 TB (TGF-beta binding) domains.

      SEQUENCE CAUTION: The sequence BAB47408.2 differs from that shown. Reason: Erroneous initiation.
      Molecular Weight~ 350 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in fresh frozen mouse skin tissue.

      Immunohistochemistry Analysis: 1:200 dilution of the antibody detected Fibrillin (Pan) in fresh frozen mouse skin tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MAB2641 04053252629112

      Documentation

      Anti-Fibrillin (Pan) Antibody, clone 689 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Fibrillin (Pan) Antibody, clone 689 Certificates of Analysis

      TitleLot Number
      Anti-Fibrillin (Pan), clone 689 - 1951948 1951948
      Anti-Fibrillin (Pan), clone 689 - 2279570 2279570
      Anti-Fibrillin (Pan), clone 689 - 2280897 2280897
      Anti-Fibrillin (Pan), clone 689 - 3530634 3530634
      Anti-Fibrillin (Pan), clone 689 - NRG1758239 NRG1758239
      Anti-Fibrillin (Pan), clone 689 -2637106 2637106
      Anti-Fibrillin (Pan), clone 689 -2888588 2888588
      Anti-Fibrillin (Pan), clone 689 Monoclonal Antibody 2961170
      Anti-Fibrillin (Pan), clone 689 Monoclonal Antibody 2981043