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MABT42 Anti-Integrin beta-2 (CD18) Antibody, clone M18/2

This Anti-Integrin beta-2 (CD18) Antibody, clone M18/2 is validated for use in FC, IP for the detection of Integrin beta-2 (CD18).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Integrins Gene Symbol: CD18, LFA-1, MAC-1, CD18, MF17, MFI7, LCAMB, LAD2 UniProt Number: P11835
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MABT42
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFC, IPRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABT42
      DescriptionAnti-Integrin beta-2 (CD18) Antibody, clone M18/2
      Alternate Names
      • integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
      • integrin beta chain, beta 2
      • complement receptor C3 beta-subunit
      • leukocyte cell adhesion molecule CD18
      • integrin beta-2
      • Complement receptor C3 subunit beta
      • Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
      • leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
      • CD18 antigen
      • integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1
      • macrophage antigen 1 (mac-1) beta subunit)
      • cell surface adhesion glycoprotein (LFA-1,CR3,P150,959 beta subunit precursor)
      • cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor)
      Background InformationIntegrin beta-2, also known as CD18, is an adhesion receptor in neutrophils that interacts with cytohesin-1 intracellularly. Integrin beta is instrumental in activation-dependent adhesion and adhesion-dependent signaling. Expression of integrin beta-2 has a positive correlation with patient survival from malignant B cell lymphoma.
      References
      Product Information
      FormatPurified
      Control
      • Mouse EL4 cells
      PresentationPurified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Integrin beta-2 (CD18) Antibody, clone M18/2 is validated for use in FC, IP for the detection of Integrin beta-2 (CD18).
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      Application NotesImmunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP (Sanchez-Madrid, F., et al. (1983). J. ExP. MED. 158:586-602).

      Inhibition Analysis: A previous lot of this antibody was shown to inhibit lymphoma metastasis (Zahalka, M. A. et al. (1993) J. Immunol. 150, 4466).
      Biological Information
      ImmunogenWhole B10 mouse spleen cells enriched with T-cells.
      Cloneclone M18/2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CD18
      • LFA-1
      • MAC-1
      • CD18
      • MF17
      • MFI7
      • LCAMB
      • LAD2
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.

      SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with COPS5 and RANBP9 (By similarity).

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

      SEQUENCE SIMILARITIES: Belongs to the integrin beta chain family.

      Contains 1 VWFA domain.
      Molecular Weight85 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in mouse EL4 cells.

      Flow Cytometry Analysis: 10 µg of this antibody detected Integrin beta-2 in mouse EL4 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABT42 04053252681820

      Documentation

      Anti-Integrin beta-2 (CD18) Antibody, clone M18/2 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Integrin beta-2 (CD18) Antibody, clone M18/2 Certificates of Analysis

      TitleLot Number
      Anti-Integrin beta-2 (CD18), -2651947 2651947
      Anti-Integrin beta-2 (CD18), -2676674 2676674
      Anti-Integrin beta-2 (CD18), clone M18/2 - 2069386 2069386
      Anti-Integrin beta-2 (CD18), clone M18/2 - 2279566 2279566
      Anti-Integrin beta-2 (CD18), clone M18/2 - 3268925 3268925
      Anti-Integrin beta-2 (CD18), clone M18/2 - 4096892 4096892
      Anti-Integrin beta-2 (CD18), clone M18/2 - NRG1833256 NRG1833256
      Anti-Integrin beta-2 (CD18), clone M18/2 Monoclonal Antibody 2979597