475876 | Mitochondrial Permeability Transition Pore Reagents Set

475876
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.





      Contains 1 g of Adenosine 5′-Diphosphate, Potassium Salt (Cat. No. 117105), 500 µg of Bongkrekic Acid, Triammonium Salt (Cat. No. 203671), 5 mg of Carboxyatractyloside, Atractylis gummifera (Cat. No. 216200), and 100 mg of Cyclosporin A, Tolypocladium inflatum (Cat. No. 239835). Supplied with a data sheet.
      Catalogue Number475876
      Brand Family Calbiochem®
      References
      Product Information
      Hygroscopic Hygroscopic
      Applications
      Biological Information
      Primary Targetcytosolic side specific mitochondrial ADP/ATP
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 23/24/25-40

      Toxic by inhalation, in contact with skin and if swallowed.
      Limited evidence of a carcinogenic effect.
      S PhraseS: 22-24/25-36/37/39-45

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Multiple Toxicity Values, refer to MSDS
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      475876
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-Febuary-2009 RFH
      DescriptionThe mitochondiral permeability transition pore (PTP) is a proteinaceous aqueous pore of about 3 nm diameter that allows compounds of less than 1500 daltons to pass through. High levels of cytosolic Ca2+ and excessive concentrations of reactive oxygen species are known to contribute to the opening of the PTP, which depolarizes the mitochondria. The opening of PTP can be blocked by a decrease of pH, increase of ADP and Mg2+ concentrations. The PTP participates in the regulation of matrix Ca2+ levels, pH, and the volume. The PTP consists of an adenine nucleotide translocator (ANT) on the inner mitochondrial membrane and a voltage-dependent anion channel (VDAC) on the outer mitochondrial membrane. Hence, the PTP appears to be mainly localized in contact sites between the two membranes. The ANT is a specific antiporter that accounts for the exchange of ATP and ADP on inner membrane. VDAC, on the other hand, serves as the primary permeability pathway for metabolite flux between cytoplasmic and mitochondrial compartments. In the low-conductance state, the opening of PTP is pH dependent, which permits the diffusion of only small ions and then closes spontaneously. However, in the high-conductance state, the channel is stabilized in an open position and allows water and bigger molecules to enter the protein rich matrix. The mechanism of PTP formation and its biological significance have important implications in cellular bioenergetics, Ca2+ signaling, and apoptosis.

      Calbiochem® brand offers a convenient Set containing 4 Mitochondrial Permeability Transition Pore Reagents with different specificities.
      Intert gas (Yes/No) Packaged under inert gas
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Toxicity Multiple Toxicity Values, refer to MSDS