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SCC173 MCA205 Mouse Fibrosarcoma Cell Line

MCA205 mouse fibrosarcoma cell line is an excellent model for studying immune response to tumor cells and the development of targeted cancer immunotherapies.

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SCC173
≥1X10⁶ cells/vial  
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC173
      DescriptionMCA205 Mouse Fibrosarcoma Cell Line
      OverviewMCA-205 is a weakly immunogenic fibrosarcoma-derived cell line that has been used in many studies to induce tumor-reactive T lymphocytes, the key aspect of adoptive immunotherapy (2). MCA-205 cells are widely utilized as stimulators for inducing cytokine expression (3). The MCA-205 mouse fibrosarcoma cell line is an excellent model for studying the immune responses to tumor cells and for supporting the development of targeted cancer immunotherapies.

      Source:
      Non-GMO. MCA-205 was derived from 3-methylcholanthrene-induced fibrosarcoma in C57BL/6 mice. Tumors were maintained in vivo by serial subcutaneous transplantation in syngeneic mice and single-cell suspensions were prepared from solid tumors by enzymatic digestion (4). From these cells the MCA-205 cell line was established and maintained in vitro.

      References:
      1. Oncotarget. 2017; 8(61): 104638-104653.
      2. Cancer Res..1996; 56(19): 4338-4342.
      3. J Immunol. 1990; 144(4): 1531-1537.
      4. J Immunol. 1988; 140: 2453-2461.
      Alternate Names
      • MCA-205
      • MCA 205
      Background InformationCancer immunotherapy is a rapidly expanding field that has produced significant advances in cancer treatment. Understanding the interactions of tumor cells with the immune system is crucial to the development of effective immunotherapeutic approaches. Fibrosarcoma is a rare yet aggressive soft-tissue sarcoma characterized by frequent tumor recurrences and a high degree of resistance to radio- and chemotherapy (1).
      References
      Product Information
      Applications
      ApplicationMCA205 mouse fibrosarcoma cell line is an excellent model for studying immune response to tumor cells and the development of targeted cancer immunotherapies.
      Key Applications
      • Cell Culture
      Application NotesThis product is sold solely for research use per the terms of the “Restricted Use Agreement” which govern its use as detailed in the product Data Sheet or Certificate of Analysis. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X10⁶ viable cells.
      • Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are negative for mycoplasma contamination
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC173 04054839607004