08-126 Vitronectin, human recombinant

500 µg  
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      Replacement Information

      Key Spec Table

      Key Applications
      PC, CULT
      Catalogue Number08-126
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionVitronectin, human recombinant
      Product Information
      PresentationLiquid in 10mM Sodium Phosphate, pH 7.1, 150mM Sodium Chloride, 0.1mM DTT, 0.1mM PMSF and 50% glycerol.
      Key Applications
      • Positive Control
      • Cell Culture
      Biological Information
      Concentration1.5 mg/mL
      SourceN-terminal, GST-tagged, full-length human Vitronectin expressed in E. coli
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond.
      Gene Symbol
      • VTN
      • VN
      • epibolin
      • V75
      • VNT
      • S-protein
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P04004 # Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
      SIZE: 478 amino acids; 54306 Da
      SUBUNIT: Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1 and insulin.
      SUBCELLULAR LOCATION: Secreted, extracellular space.
      DOMAIN: SwissProt: P04004 The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
      PTM: Sulfated on 2 tyrosine residues. & N- and O-glycosylated (By similarity). & Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading. & It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.SIMILARITY: Contains 4 hemopexin-like domains. & Contains 1 SMB (somatomedin-B) domain.
      Stem Cell Type
      • Human Embryonic Stem Cells
      • Mesenchymal Stem Cells
      • Neural Stem Cells
      • Hematopoietic Stem Cells
      • Epithelial Cells
      • Pancreatic Stem Cells
      • Induced Pluripotent Stem Cells
      Molecular Weight78 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by cell adhesion assay.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -20°C from date of shipment
      Packaging Information
      Material Size500 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Vitronectin, human (recombinant protein expressed in E. coli) - 24333902433390
      Vitronectin, human (recombinant protein expressed in E. coli)2910182
      Vitronectin, human (recombinant protein expressed in E. coli)3088382
      Vitronectin, human (recombinant protein expressed in E. coli)3129989
      Vitronectin, human (recombinant protein expressed in E. coli)2929170
      Vitronectin, human (recombinant protein expressed in E. coli) - 20033452003345
      Vitronectin, human (recombinant protein expressed in E. coli) - 22094442209444
      Vitronectin, human (recombinant protein expressed in E. coli) - 29706782970678
      Vitronectin, human (recombinant protein expressed in E. coli) - JBC1947705JBC1947705
      Vitronectin, human - 28285622828562


      Reference overviewPub Med ID
      Expression, production, and characterization of full-length vitronectin in Escherichia coli
      Wojciechowski, Katherine, et al
      Protein Expr Purif, 36:131-8 (2004)  2004

      15177294 15177294
      Caught in the matrix: how vitronectin controls neuronal differentiation.
      Wechsler-Reya, R J
      Trends Neurosci., 24: 680-2 (2001)  2001

      Show Abstract
      11718852 11718852
      Schvartz, I, et al.
      Int. J. Biochem. Cell Biol., 31: 539-44 (1999)  1999

      Show Abstract
      10399314 10399314


      Human Stem Cell Systems