407247
IGF-1R Inhibitor, PPP
Insulin-like Growth Factor-1 Receptor Inhibitor, Picropodophyllin
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Merck KGaA
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64293 Darmstadt
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19 June 2013
loading
| Product number | Qty/Pk |
|---|---|
| 407247-1MG | 1 mg |
A cell-permeable cis-cyclolignan compound that acts as a substrate competitive, reversible, potent, and specific inhibitor of IGF-1R both in vitro (IC50 = 1 nM in cell-free kinase assay; ≤ 60 nM for cell viability and receptor autophosphorylation in melanoma cell lines) and in vivo (complete inhibition of IGF-1R-dependent tumor cell growth at 20 mg/kg/12 hr, i.p., in SCID mice) with minimum toxic effect (LD50 > 500 mg/kg). Exhibits little effect towards IR, FGFR, PDGFR and EGFR, and exerts no effects on microtubules and DNA topoisomerase II. Targets the phosphorylation of Y1136 in the activation loop and is the first inhibitor reported to discriminate between IGF-1R and IR.
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Primary Target | IGF-1R both in vitro | ||
| Primary Target IC50 | 1 nM in cell-free kinase assay | ||
| Molar mass | 414.4 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C22H22O8 | ||
| CAS number | 477-47-4 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Carcinogenic / Teratogenic |
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