574102
Sulindac Sulfide
(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefone: +49 6151 72-0
Fax: +49 6151 72 2000
28 Maio 2012
carregando
| Nº de produto | Qt/Emb |
|---|---|
| 574102-5MG | 5 mg |
A cell-permeable, active metabolite of Sulindac (Cat. No. 574100). Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits growth and induces apoptosis in prostate cancer cell lines. Selectively inhibits COX-1 (ID50 = 500 nM) compared to prostaglandin H synthase-2 (PGHS-2; COX-2; ID50 = 14 µM). Preferentially inhibits the secretion of Aβ42 in CHO cells stably transfected with both APP75, and the PS1 mutant M146L.
| Informações sobre o produto | |||
|---|---|---|---|
| Form | Yellow-orange solid | ||
| Primary Target | COX-1 | ||
| Primary Target IC50 | ID50 = 500 nM | ||
| Secondary target | PGHS-2; COX-2; ID50 = 14 µM | ||
| Cell permeable | Sim | ||
| Purity | ≥98% by TLC | ||
| Fórmula Química | C20H17FO2S | ||
| Número CAS | 32004-67-4 | ||
| Informação de estoque e transporte | |||
|---|---|---|---|
| Armazenagem | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Harmful & Carcinogenic / Teratogenic |
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| Informações de segurança | |||
|---|---|---|---|
| Frases S |
S: 36 |
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| Frases R |
R: 22-42/43-63 |
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