420120  Juglone

5-Hydroxy-1,4-naphthlenedione, 5-Hydroxy-p-naphthoquinone

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64293 Darmstadt
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17 April 2014

Product number Qty/Pk Quantity Price
420120-250MG  250 mg  loading
Prices are subject to change without notice.
A highly selective cell-permeable, irreversible inhibitor of PPlases (peptidyl-prolyl cis/trans isomerases of the parvulin family). Other known PPlase inhibitors such as cyclosporin A, FK506, and rapamycin are not reported to inhibit the parvulin family of PPlases. The inactivation is shown to occur via the addition of thiol groups to juglone and not by any redox process. Exhibits bacteriostatic and fungistatic effects. Reported to be cytotoxic towards eukaryotic cells and to block transcription by RNA polymerase II.
Product information
Form Orange solid
Molar mass 174.2
Protect from Light Yes
Packaged under inert gas Yes
Purity ≥95% by HPLC
Solubility DMSO or EtOH
Chemical formula C10H6O3
RTECS QJ5775000
CAS number 481-39-0
Merck USA index 14, 5269
Store and ship information

Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Storage +2°C to +8°C
Ship Ambient Temperature Only
Safety information
S Phrase S: 45-26

In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
R Phrase R: 36/37/38-25

Irritating to eyes, respiratory system and skin.
Toxic if swallowed.
Juglone, molecular structure

© Merck KGaA, Darmstadt, Germany, 2014


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