219505
CBFβ Inhibitor
5-Ethyl-4-(4′-methoxyphenyl)-thiazolyl-2-amine
Untuk pertanyaan umum, silakan hubungi Layanan Pelanggan kami:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefon: +49 6151 72-0
Faks: +49 6151 72 2000
31 May 2012
memuat
A cell-permeable thiazolyl compound that binds to CBFβ (core binding factor β) and allosterically disrupts CBFα/Runx1 binding to CBFβ both in cell-free binding studies (IC50 of ~3.5 µM by FRET and ELISA) and in HEK293 cells (IC50 of ~ 100 µM by FACS/FRET). Cellular studies indicate a good correlation between the inhibitor's antiproliferative activity and the Runx1 expression level in the target cells.
| Informasi produk | |||
|---|---|---|---|
| Form | Tan solid | ||
| Protect from Light | Ya | ||
| Purity | ≥97% by HPLC | ||
| Formulasi kimia | C12H14N2OS | ||
| Nomor CAS | 493028-20-9 | ||
| Simpan dan kirim informasi | |||
|---|---|---|---|
| Penyimpanan | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
| Informasi keselamatan kerja | |||
|---|---|---|---|
| Frase S |
S: 24/25 |
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