344559
FTI-2628
2-(((5-((1H-Imidazol-4-ylmethyl)-amino)-methyl)-2′-methyl-biphenyl-2-carbonyl)-amino)-4-methylsulfanyl-butyric acid benzyl ester
Untuk pertanyaan umum, silakan hubungi Layanan Pelanggan kami:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefon: +49 6151 72-0
Faks: +49 6151 72 2000
31 May 2012
memuat
A cell-permeable benzyl ester prodrug form of FTI-2148 (Cat. No. 344557) that preferentially inhibits protein farnesyltransferase activity (IC50 = 530 nM for mammalian and 1.0 µM for P. falciparum) over protein geranylgeranyltransferase-I (IC50 > 10 µM for mammalian) and displays anti-malarial properties. Potently disrupts Ras farnesylation in H-Ras-transformed NIH 3T3 cells (IC50 = 20 nM) and inhibits the growth of P. falciparum in red blood cells (ED50 = 150 nM). Also suppresses parasitemia in P. berghei-infected mice by 46.1% (50 mg/kg, ip) with no apparent toxicity.
| Informasi produk | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | PFTase | ||
| Primary Target IC50 | 530 nM (mammalian) | ||
| Secondary target | protein geranylgeranyltransferase-I (IC50 > 10 µM for mammalian) | ||
| Protect from Light | Ya | ||
| Packaged under inert gas | Ya | ||
| Cell permeable | Ya | ||
| Purity | ≥95% by HPLC | ||
| Formulasi kimia | C31H34N4O3S | ||
| Simpan dan kirim informasi | |||
|---|---|---|---|
| Penyimpanan | -20°C | ||
| Ship |
Shipped with Blue Ice or with Dry Ice
Standard Handling |
||
