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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefon: +49 6151 72-0
Faks: +49 6151 72 2000
31 May 2012
memuat
A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50 = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca2+ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells. Also inhibits neutrophil chemotaxis induced by NO donors.
| Informasi produk | |||
|---|---|---|---|
| Form | Reddish purple solid | ||
| Primary Target | soluble guanylate cyclase | ||
| Primary Target IC50 | 2 µM | ||
| Cell permeable | Ya | ||
| Purity | ≥98% by TLC and HPLC | ||
| Formulasi kimia | C15H10N2O2 | ||
| Nomor CAS | 91300-60-6 | ||
| Simpan dan kirim informasi | |||
|---|---|---|---|
| Penyimpanan | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Harmful & Carcinogenic / Teratogenic |
||
| Informasi keselamatan kerja | |||
|---|---|---|---|
| Frase S |
S: 22-26-36/37/39-45 |
||
| Frase R |
R: 22-36/37/38-45-46-48 |
||
