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407850 PARP Inhibitor II, INH₂BP

PARP Inhibitor II, INH₂BP MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-Iodo-6-amino-1,2-benzopyrone

Primary Target: PARP
407850
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      137881-27-7C₉H₆INO₂
      Description
      Overview

      This product has been discontinued.





      A cell-permeable poly(ADP-ribose) polymerase (PARP) inhibitor. Offers protection against peroxynitrite and hydroxyl radicals in vitro and in vivo and abrogates peroxynitrite-induced mitochondrial transmembrane potential (ΔΨm) reduction. Also exhibits malignant phenotype reversal in cancer cells and inhibits HIV-1 IIIb replication in vitro.
      Catalogue Number407850
      Brand Family Calbiochem®
      Synonyms5-Iodo-6-amino-1,2-benzopyrone
      References
      ReferencesSzabó, C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3867.
      Szabó, C. 1998. Shock 9, 341.
      Virag, L., et al. 1998. J. Immunol. 161, 3753.
      Bauer, P.I., et al. 1995. Biochimie 77, 374.
      Cole, G.A., et al. 1991. Biochem. Biophys. Res. Commun. 180, 504.
      Product Information
      CAS number137881-27-7
      ATP CompetitiveY
      FormYellow to gold solid
      Hill FormulaC₉H₆INO₂
      Chemical formulaC₉H₆INO₂
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetPARP
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      407850 0

      Documentation

      References

      Reference overview
      Szabó, C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3867.
      Szabó, C. 1998. Shock 9, 341.
      Virag, L., et al. 1998. J. Immunol. 161, 3753.
      Bauer, P.I., et al. 1995. Biochimie 77, 374.
      Cole, G.A., et al. 1991. Biochem. Biophys. Res. Commun. 180, 504.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-July-2008 RFH
      Synonyms5-Iodo-6-amino-1,2-benzopyrone
      DescriptionA lipophilic PARP [poly (ADP-ribose) polymerase] inhibitor. Offers protection against peroxynitrite and hydroxyl radicals in vitro and in vivo and abrogates peroxynitrite-induced mitochodrial transmembrane potential (ΔΨm) reduction. Also exhibits malignant phenotype reversal in cancer cells and inhibits HIV-1 IIIb replication in vitro.
      FormYellow to gold solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number137881-27-7
      Chemical formulaC₉H₆INO₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSzabó, C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3867.
      Szabó, C. 1998. Shock 9, 341.
      Virag, L., et al. 1998. J. Immunol. 161, 3753.
      Bauer, P.I., et al. 1995. Biochimie 77, 374.
      Cole, G.A., et al. 1991. Biochem. Biophys. Res. Commun. 180, 504.