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メルク株式会社
目黒区下目黒1-8-1
153-8927 東京
Japan
TEL： 0120-189-390
Fax: 0120-189-350
E-mail mj_service@merckgroup.com
31 5月 2012
ローディング
A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50 = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca2+ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells. Also inhibits neutrophil chemotaxis induced by NO donors.
| 製品情報 | |||
|---|---|---|---|
| Form | Reddish purple solid | ||
| Primary Target | soluble guanylate cyclase | ||
| Primary Target IC50 | 2 µM | ||
| Cell permeable | はい | ||
| Purity | ≥98% by TLC and HPLC | ||
| 化学式 | C15H10N2O2 | ||
| CAS 番号 | 91300-60-6 | ||
| 保管と送付情報 | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Harmful & Carcinogenic / Teratogenic |
||
| 安全性情報 | |||
|---|---|---|---|
| S フレーズ |
S: 22-26-36/37/39-45 |
||
| R フレーズ |
R: 22-36/37/38-45-46-48 |
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