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メルク株式会社
目黒区下目黒1-8-1
153-8927 東京
Japan
TEL： 0120-189-390
Fax: 0120-189-350
E-mail mj_service@merckgroup.com
31 5月 2012
ローディング
A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering their interaction with the Rac-specific GEF (guanine nucleotide exchange factor) Trio and Tiam1 (IC50 ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 µM). Exhibits no effect on Cdc42 or RhoA activation, and does it affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC50 = 50 mM and 64 mM, respectively). A 50 mM (5 mg/185 µl) solution of Rac1 Inhibitor (Cat. No. 553508) in H2O is also available.
| 製品情報 | |||
|---|---|---|---|
| Form | Lyophilized | ||
| Protect from Light | はい | ||
| Hygrocopic | はい | ||
| Packaged under inert gas | はい | ||
| Purity | ≥93% by HPLC | ||
| 化学式 | C24H38Cl3N7 | ||
| CAS 番号 | 1177865-17-6 | ||
| 保管と送付情報 | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Carcinogenic / Teratogenic |
||
