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31 May 2012
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A potent, irreversible inhibitor of serine proteases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Inhibits granzyme B and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Does not affect thiol proteases and metalloproteases. Does not exhibit any activity towards β-lactamases.
Effective concentration: 5-100 µM; t½ = 20 min at pH 7.5.
| Product information | |||
|---|---|---|---|
| Form | White lyophilized solid | ||
| Primary Target | serine proteases | ||
| Primary Target IC50 | 5-100 µM | ||
| Secondary target | granzyme B | ||
| Molar mass | 215.0 | ||
| Protect from Moisture | Yes | ||
| Purity | ≥99% by elemental analysis | ||
| Solubility | DMF or DMSO | ||
| Chemical formula | C9H4Cl2O2 | ||
| CAS number | 51050-59-0 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
