171588
Aβ42 Fibrillogenesis Inhibitor III
Amyloid β42 Fibrillogenesis Inhibitor III, iAβ5p, Ac-LPFFD-NH2
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Merck KGaA
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64293 Darmstadt
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Fax: +49 6151 72 2000
31 May 2012
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A modified analog of Aβ42 Fibrillogenesis Inhibitor I (Cat. No. 171586) that crosses the blood-brain barrier and acts as a β-sheet breaker. Reported to increase neuronal survival and reduce brain inflammation in a transgenic mouse model of Alzheimer’s disease, probably due to a reduction in Aβ deposits. Displays greater stability against proteolytic degradation (t1/2 > 24 hours in human plasma and cerebrospinal fluid; ~ 37 minutes in blood).
| Product information | |||
|---|---|---|---|
| Peptide Sequence | Ac-Leu-Pro-Phe-Phe-Asp-NH2 | ||
| Form | White solid | ||
| Molar mass | 678.8 | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C35H46N6O8 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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