116825
Adenosine 3′,5′-cyclic Monophosphorothioate, 2′-O-Monobutyryl-, Rp-Isomer, Sodium Salt
Rp-MB-cAMPS, Na
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31 May 2012
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A cell-permeable, metabolically-stable precursor of Rp-cAMPS (Cat. No. 116814) that acts as a competitive inhibitor of protein kinase A type I and II. During metabolic activation by esterases, the inhibitor and butyrate are released. Reported to inhibit glucose-induced proliferation of the pancreatic β-cell line, INS-1. More lipophilic and cell-permeable than Rp-cAMPS.
Note: 5 µmol = 2.19 mg.
| Product information | |||
|---|---|---|---|
| Form | Lyophilized | ||
| Primary Target | PKA1, PKA2 | ||
| Secondary target | PI3K (IC50 = 83 µM) | ||
| Molar mass | 437.3 | ||
| Hygrocopic | Yes | ||
| Cell permeable | Yes | ||
| ATP Competitive | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | H2O | ||
| Chemical formula | C14H17N5O6PS · Na | ||
| CAS number | 152218-23-0 | ||
| Declaration | Sold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI. | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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